Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region.
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Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cellsIdentification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeatsEvolution of distinct EGF domains with specific functionsProtein O-fucosyltransferase 1 is an essential component of Notch signaling pathwaysHijacking the Hexosamine Biosynthetic Pathway to Promote EMT-Mediated Neoplastic PhenotypesFringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligandsMolecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notchO-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamilyNotch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse developmentFringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1O-fucosylation of the notch ligand mDLL1 by POFUT1 is dispensable for ligand functionO-fucosylation of DLL3 is required for its function during somitogenesisProtein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2Role of glycosylation of Notch in developmentRole of glycans and glycosyltransferases in the regulation of Notch signalingFringe benefits: functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptorsGlycosylation regulates Notch signalling.Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO (VWA2 protein).O-fucose monosaccharide of Drosophila Notch has a temperature-sensitive function and cooperates with O-glucose glycan in Notch transport and Notch signaling activationFunctional UDP-xylose transport across the endoplasmic reticulum/Golgi membrane in a Chinese hamster ovary cell mutant defective in UDP-xylose SynthaseMultiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling.O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1.Galactose differentially modulates lunatic and manic fringe effects on Delta1-induced NOTCH signaling.Regulation of Notch signaling by glycosylation.Site-specific O-glucosylation of the epidermal growth factor-like (EGF) repeats of notch: efficiency of glycosylation is affected by proper folding and amino acid sequence of individual EGF repeatsThe O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development.6-alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2.Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.Role of unusual O-glycans in intercellular signalingManic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain.Vertebrate protein glycosylation: diversity, synthesis and function.S/T phosphorylation of DLL1 is required for full ligand activity in vitro but dispensable for DLL1 function in vivo during embryonic patterning and marginal zone B cell development.Myeloproliferation and hematopoietic stem cell dysfunction due to defective Notch receptor modification by O-fucose glycans.Significance of glycosylation in Notch signaling.Polysialic acid: biosynthesis, novel functions and applications.Roles of Pofut1 and O-fucose in mammalian Notch signaling.Biological functions of fucose in mammals.Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies.Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands.
P2860
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P2860
Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region.
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Fringe modifies O-fucose on mo ...... site and the Abruptex region.
@ast
Fringe modifies O-fucose on mo ...... site and the Abruptex region.
@en
Fringe modifies O-fucose on mo ...... site and the Abruptex region.
@nl
type
label
Fringe modifies O-fucose on mo ...... site and the Abruptex region.
@ast
Fringe modifies O-fucose on mo ...... site and the Abruptex region.
@en
Fringe modifies O-fucose on mo ...... site and the Abruptex region.
@nl
prefLabel
Fringe modifies O-fucose on mo ...... site and the Abruptex region.
@ast
Fringe modifies O-fucose on mo ...... site and the Abruptex region.
@en
Fringe modifies O-fucose on mo ...... site and the Abruptex region.
@nl
P2093
P2860
P356
P1476
Fringe modifies O-fucose on mo ...... site and the Abruptex region.
@en
P2093
Daniel J Moloney
Robert Haltiwanger
P2860
P304
P356
10.1074/JBC.M212221200
P407
P577
2002-12-16T00:00:00Z