The moderately efficient enzyme: evolutionary and physicochemical trends shaping enzyme parameters.
about
Intrinsic noise analyzer: a software package for the exploration of stochastic biochemical kinetics using the system size expansionIncreased Diels-Alderase activity through backbone remodeling guided by Foldit players.The Enzyme Function Initiative.How special is the biochemical function of native proteins?Bridging scales through multiscale modeling: a case study on protein kinase AThe Impact of Non-Enzymatic Reactions and Enzyme Promiscuity on Cellular Metabolism during (Oxidative) Stress ConditionsSingle-molecule enzymology à la Michaelis-MentenHDAC8 substrates: Histones and beyondA survey of carbon fixation pathways through a quantitative lensImplications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical functionEvolutionary pressures on microbial metabolic strategies in the chemostatConditional iron and pH-dependent activity of a non-enzymatic glycolysis and pentose phosphate pathwayStructural Analyses of Covalent Enzyme–Substrate Analog Complexes Reveal Strengths and Limitations of De Novo Enzyme DesignStructure and function of an insect -carboxylesterase ( Esterase7) associated with insecticide resistanceMolecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase TemplateGround state destabilization by anionic nucleophiles contributes to the activity of phosphoryl transfer enzymesDiscovery of new enzymes and metabolic pathways by using structure and genome contextStructural and Enzymatic Characterization of the Phosphotriesterase OPHC2 from Pseudomonas pseudoalcaligenesBridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59Impact of scaffold rigidity on the design and evolution of an artificial Diels-AlderaseRational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiencyPhenotypic comparisons of consensus variants versus laboratory resurrections of Precambrian proteinsMINEs: open access databases of computationally predicted enzyme promiscuity products for untargeted metabolomicsEnzymatic hydrolysis by transition-metal-dependent nucleophilic aromatic substitutionStructure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymesStructural and biochemical characterization of Chlamydia trachomatis hypothetical protein CT263 supports that menaquinone synthesis occurs through the futalosine pathway.Computing the functional proteome: recent progress and future prospects for genome-scale modelsOver expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NFκB responsesA high-throughput colorimetric screening assay for terpene synthase activity based on substrate consumptionEfficient Characterization of Parametric Uncertainty of Complex (Bio)chemical NetworksCatalysis and Structure of Zebrafish Urate Oxidase Provide Insights into the Origin of Hyperuricemia in HominoidsRapid bursts and slow declines: on the possible evolutionary trajectories of enzymesIntracellular metabolite levels shape sulfur isotope fractionation during microbial sulfate respirationQuantification and Classification of E. coli Proteome Utilization and Unused Protein Costs across Environments.On the role of physics and evolution in dictating protein structure and functionThe dynamical nature of enzymatic catalysis.Computational protein engineering: bridging the gap between rational design and laboratory evolution.The rise of chemodiversity in plants.Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform.Design Principles as a Guide for Constraint Based and Dynamic Modeling: Towards an Integrative Workflow.
P2860
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P2860
The moderately efficient enzyme: evolutionary and physicochemical trends shaping enzyme parameters.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The moderately efficient enzym ...... nds shaping enzyme parameters.
@ast
The moderately efficient enzym ...... nds shaping enzyme parameters.
@en
The moderately efficient enzym ...... nds shaping enzyme parameters.
@nl
type
label
The moderately efficient enzym ...... nds shaping enzyme parameters.
@ast
The moderately efficient enzym ...... nds shaping enzyme parameters.
@en
The moderately efficient enzym ...... nds shaping enzyme parameters.
@nl
prefLabel
The moderately efficient enzym ...... nds shaping enzyme parameters.
@ast
The moderately efficient enzym ...... nds shaping enzyme parameters.
@en
The moderately efficient enzym ...... nds shaping enzyme parameters.
@nl
P2093
P50
P356
P1433
P1476
The moderately efficient enzym ...... nds shaping enzyme parameters.
@en
P2093
Dan Davidi
Dan S Tawfik
Yonatan Savir
P304
P356
10.1021/BI2002289
P407
P577
2011-05-04T00:00:00Z