Properties of deoxyribonuclease 3 from mammalian tissues.
about
Trex1 prevents cell-intrinsic initiation of autoimmunityThe enemy within: endogenous retroelements and autoimmune diseaseStructural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleasesProcessing of damaged DNA ends for double-strand break repair in mammalian cellsMouse models for Aicardi-Goutières syndrome provide clues to the molecular pathogenesis of systemic autoimmunityNew roles for the major human 3'-5' exonuclease TREX1 in human disease.The Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers.Simple and convenient G-quadruplex-based turn-on fluorescence assay for 3' → 5' exonuclease activity.Interferon regulatory factors: critical mediators of human lupus.Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome.cGMP-AMP synthase paves the way to autoimmunityTREX1 acts in degrading damaged DNA from drug-treated tumor cells.DNA binding induces active site conformational change in the human TREX2 3'-exonucleaseConnections between antiviral defense and autoimmunity.Endogenous retroelements and autoimmune disease.Telomeres in cancer: tumour suppression and genome instability.Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage.Adenovirus-induced inhibition of cellular DNase.Evidence for two waves of induction of DNA enzymes in stimulated human lymphocytes.Cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonucleaseResolution of synthetic Holliday junctions in DNA by an endonuclease activity from calf thymus.Tracking interferon in autoimmunity.TREX2 exonuclease defective cells exhibit double-strand breaks and chromosomal fragments but not Robertsonian translocations.DDX41 Recognizes RNA/DNA Retroviral Reverse Transcripts and Is Critical for In Vivo Control of Murine Leukemia Virus Infection.
P2860
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P2860
Properties of deoxyribonuclease 3 from mammalian tissues.
description
1969 nî lūn-bûn
@nan
1969 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1969 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1969年の論文
@ja
1969年論文
@yue
1969年論文
@zh-hant
1969年論文
@zh-hk
1969年論文
@zh-mo
1969年論文
@zh-tw
1969年论文
@wuu
name
Properties of deoxyribonuclease 3 from mammalian tissues.
@ast
Properties of deoxyribonuclease 3 from mammalian tissues.
@en
Properties of deoxyribonuclease 3 from mammalian tissues.
@nl
type
label
Properties of deoxyribonuclease 3 from mammalian tissues.
@ast
Properties of deoxyribonuclease 3 from mammalian tissues.
@en
Properties of deoxyribonuclease 3 from mammalian tissues.
@nl
prefLabel
Properties of deoxyribonuclease 3 from mammalian tissues.
@ast
Properties of deoxyribonuclease 3 from mammalian tissues.
@en
Properties of deoxyribonuclease 3 from mammalian tissues.
@nl
P1476
Properties of deoxyribonuclease 3 from mammalian tissues.
@en
P2093
P304
P407
P577
1969-09-01T00:00:00Z