Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor.
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Potent Elastase Inhibitors from Cyanobacteria: Structural Basis and Mechanisms Mediating Cytoprotective and Anti-Inflammatory Effects in Bronchial Epithelial CellsCalcarides A-E, antibacterial macrocyclic and linear polyesters from a Calcarisporium strain.Largazole Arrests Cell Cycle at G1 Phase and Triggers Proteasomal Degradation of E2F1 in Lung Cancer Cells.Association of Smoking, Alcohol Use, and Betel Quid Chewing with Epigenetic Aberrations in Cancers.Evaluation of class I HDAC isoform selectivity of largazole analoguesModulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug PropertiesA searchable cross-platform gene expression database reveals connections between drug treatments and disease.Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groupsVeraguamides A-G, cyclic hexadepsipeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam.In Vitro and In Vivo Osteogenic Activity of Largazole.Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activityBiological targets and mechanisms of action of natural products from marine cyanobacteria.Comparative pharmacokinetic properties and antitumor activity of the marine HDACi Largazole and Largazole peptide isostereLargazole: from discovery to broad-spectrum therapy.Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanismsDiscovery and mechanism of natural products as modulators of histone acetylation.Largazole pharmacokinetics in rats by LC-MS/MS.The role of dietary histone deacetylases (HDACs) inhibitors in health and disease.Synthesis and biological evaluation of largazole zinc-binding group analogs.Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes.The carmaphycins: new proteasome inhibitors exhibiting an α,β-epoxyketone warhead from a marine cyanobacterium.Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation.Total synthesis and biological evaluation of grassypeptolide A.Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue.Genome-wide dose-dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super-enhancers.Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships.Therapeutic Properties and Biological Benefits of Marine-Derived Anticancer Peptides.Molecular Targets of Active Anticancer Compounds Derived from Marine Sources.Chiral Mercaptoacetamides Display Enantioselective Inhibition of Histone Deacetylase 6 and Exhibit Neuroprotection in Cortical Neuron Models of Oxidative StressAntiangiogenic therapy for portal hypertension in liver cirrhosis: Current progress and perspectives
P2860
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P2860
Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Anticolon cancer activity of l ...... histone deacetylase inhibitor.
@ast
Anticolon cancer activity of l ...... histone deacetylase inhibitor.
@en
Anticolon cancer activity of l ...... histone deacetylase inhibitor.
@nl
type
label
Anticolon cancer activity of l ...... histone deacetylase inhibitor.
@ast
Anticolon cancer activity of l ...... histone deacetylase inhibitor.
@en
Anticolon cancer activity of l ...... histone deacetylase inhibitor.
@nl
prefLabel
Anticolon cancer activity of l ...... histone deacetylase inhibitor.
@ast
Anticolon cancer activity of l ...... histone deacetylase inhibitor.
@en
Anticolon cancer activity of l ...... histone deacetylase inhibitor.
@nl
P2093
P2860
P356
P1476
Anticolon cancer activity of l ...... histone deacetylase inhibitor
@en
P2093
Brian K Law
Hendrik Luesch
Jiyong Hong
Lilibeth A Salvador
Seongrim Byeon
Yanxia Liu
Yongcheng Ying
P2860
P304
P356
10.1124/JPET.110.172387
P407
P50
P577
2010-08-25T00:00:00Z