Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs.
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The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transportersReduced Ribavirin Antiviral Efficacy via Nucleoside Transporter-Mediated Drug ResistanceLimited dCTP availability accounts for mitochondrial DNA depletion in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosidesNeurotoxic effects of AZT on developing and adult neurogenesisXenobiotic, bile acid, and cholesterol transporters: function and regulation.Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.Zidovudine inhibits thymidine phosphorylation in the isolated perfused rat heart.Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance: transgenic TK2, mtDNA, and antiretrovirals.MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in MitochondriaThymidine and deoxyuridine accumulate in tissues of patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)Does mitochondrial dysfunction during antiretroviral therapy in human immunodeficiency virus infection suggest antioxidant supplementation as a beneficial option?Antiretroviral therapy and the kidney: balancing benefit and risk in patients with HIV infection.Renal nucleoside transporters: physiological and clinical implications.Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes.The role of transporters in the toxicity of nucleoside and nucleotide analogs.The H syndrome is caused by mutations in the nucleoside transporter hENT3.The role of mitochondrial and plasma membrane nucleoside transporters in drug toxicity.Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3.Drug transporter pharmacogenetics in nucleoside-based therapies.Transporters that translocate nucleosides and structural similar drugs: structural requirements for substrate recognition.Nucleoside/nucleobase transporters: drug targets of the future?The mechanistic basis for the induction of hepatic steatosis by xenobiotics.Inhibition of Transient Receptor Potential Channel Mucolipin-1 (TRPML1) by Lysosomal Adenosine Involved in Severe Combined Immunodeficiency Diseases.Neurotoxicity in the Post-HAART Era: Caution for the Antiretroviral Therapeutics.Importance of Hepatic Transporters in Clinical Disposition of Drugs and Their Metabolites.In vitro-in vivo correlation of hepatobiliary drug clearance in humans.Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine.Subtype-specific regulation of equilibrative nucleoside transporters by protein kinase CK2.Mitochondrial deoxyribonucleotides, pool sizes, synthesis, and regulation.The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase.A Single Zidovudine (AZT) Administration Delays Hepatic Cell Proliferation by Altering Oxidative State in the Regenerating Rat Liver.Synthesis, modeling and evaluation of 3'-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3'-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors.In situ hybridization and immunolocalization of concentrative and equilibrative nucleoside transporters in the human intestine, liver, kidneys, and placenta
P2860
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P2860
Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs.
description
2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Mitochondrial expression of th ...... l toxicity of antiviral drugs.
@ast
Mitochondrial expression of th ...... l toxicity of antiviral drugs.
@en
Mitochondrial expression of the human equilibrative nucleoside transporter 1
@nl
type
label
Mitochondrial expression of th ...... l toxicity of antiviral drugs.
@ast
Mitochondrial expression of th ...... l toxicity of antiviral drugs.
@en
Mitochondrial expression of the human equilibrative nucleoside transporter 1
@nl
prefLabel
Mitochondrial expression of th ...... l toxicity of antiviral drugs.
@ast
Mitochondrial expression of th ...... l toxicity of antiviral drugs.
@en
Mitochondrial expression of the human equilibrative nucleoside transporter 1
@nl
P356
P1476
Mitochondrial expression of th ...... al toxicity of antiviral drugs
@en
P2093
Chung-Ming Tse
Jashvant D Unadkat
P304
P356
10.1074/JBC.M307938200
P407
P50
P577
2003-11-07T00:00:00Z