A conserved domain of Schizosaccharomyces pombe dfp1(+) is uniquely required for chromosome stability following alkylation damage during S phase
about
A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replicationCdc7p-Dbf4p regulates mitotic exit by inhibiting Polo kinase.The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffoldsThe C-terminus of S. pombe DDK subunit Dfp1 is required for meiosis-specific transcription and cohesin cleavage.Cell cycle regulation of chromatin binding and nuclear localization of human Cdc7-ASK kinase complex.Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage.Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage.Phosphorylation of Mcm2 modulates Mcm2-7 activity and affects the cell's response to DNA damageA genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damageA Dbf4p BRCA1 C-terminal-like domain required for the response to replication fork arrest in budding yeast.Eukaryotic MCM proteins: beyond replication initiation.Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.Cell cycle regulation of DNA replication.Dbf4: the whole is greater than the sum of its partsBudding yeast Dbf4 sequences required for Cdc7 kinase activation and identification of a functional relationship between the Dbf4 and Rev1 BRCT domainsProduction of reactive oxygen species in response to replication stress and inappropriate mitosis in fission yeast.Cds1 controls the release of Cdc14-like phosphatase Flp1 from the nucleolus to drive full activation of the checkpoint response to replication stress in fission yeast.ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stressA synthetic human kinase can control cell cycle progression in budding yeast.DNA replication checkpoint signaling depends on a Rad53-Dbf4 N-terminal interaction in Saccharomyces cerevisiae.Rad53 regulates replication fork restart after DNA damage in Saccharomyces cerevisiae.A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents.Drug design with Cdc7 kinase: a potential novel cancer therapy target.Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing.Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognitionSchizosaccharomyces pombe Ddb1 is functionally linked to the replication checkpoint pathway.Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex.Profiling of ribonucleotides and deoxyribonucleotides pools in response to DNA damage and repair induced by methyl methanesulfonate in cancer and normal cells.Cdc7 is an active kinase in human cancer cells undergoing replication stress.
P2860
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P2860
A conserved domain of Schizosaccharomyces pombe dfp1(+) is uniquely required for chromosome stability following alkylation damage during S phase
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
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name
A conserved domain of Schizosaccharomyces pombe dfp1
@nl
A conserved domain of Schizosa ...... kylation damage during S phase
@ast
A conserved domain of Schizosa ...... kylation damage during S phase
@en
type
label
A conserved domain of Schizosaccharomyces pombe dfp1
@nl
A conserved domain of Schizosa ...... kylation damage during S phase
@ast
A conserved domain of Schizosa ...... kylation damage during S phase
@en
prefLabel
A conserved domain of Schizosaccharomyces pombe dfp1
@nl
A conserved domain of Schizosa ...... kylation damage during S phase
@ast
A conserved domain of Schizosa ...... kylation damage during S phase
@en
P2093
P2860
P1476
A conserved domain of Schizosa ...... kylation damage during S phase
@en
P2093
Amy D Fung
Jiongwen Ou
Stephanie Bueler
P2860
P304
P356
10.1128/MCB.22.13.4477-4490.2002
P407
P577
2002-07-01T00:00:00Z