The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling
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Activation and allosteric modulation of a muscarinic acetylcholine receptorThe pathway of ligand entry from the membrane bilayer to a lipid G protein-coupled receptor.A new mechanism of allostery in a G protein-coupled receptor dimerA dynamic view of molecular switch behavior at serotonin receptors: implications for functional selectivityMapping of allosteric druggable sites in activation-associated conformers of the M2 muscarinic receptorTransmembrane peptides as unique tools to demonstrate the in vivo action of a cross-class GPCR heterocomplex.Tyrosine 308 is necessary for ligand-directed Gs protein-biased signaling of β2-adrenoceptor.Differences in allosteric communication pipelines in the inactive and active states of a GPCR.Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonistSemisynthetic analogues of toxiferine I and their pharmacological properties at α7 nAChRs, muscle-type nAChRs, and the allosteric binding site of muscarinic M2 receptors.Allosteric Activation of a G Protein-coupled Receptor with Cell-penetrating Receptor MimeticsAdvances in receptor conformation research: the quest for functionally selective conformations focusing on the β2-adrenoceptorThe Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules.Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor.Molecular alliance-from orthosteric and allosteric ligands to dualsteric/bitopic agonists at G protein coupled receptors.Harnessing allostery: a novel approach to drug discovery.Muscarinic acetylcholine receptors: novel opportunities for drug development.Superagonism at G protein-coupled receptors and beyond.Optical probes based on G protein-coupled receptors - added work or added value?Signaling within Allosteric Machines: Signal Transmission Pathways Inside G Protein-Coupled Receptors.Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology.Label-free cell-based dynamic mass redistribution assays.Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-coupled Receptor.Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the β2-adrenoceptor.A Photoswitchable Dualsteric Ligand Controlling Receptor Efficacy.A muscarinic view on Gq.Bitopic muscarinic agonists and antagonists and uses thereof: a patent evaluation of US20160136145A1.Structural Characteristics of the Allosteric Binding Site Represent a Key to Subtype Selective Modulators of Muscarinic Acetylcholine Receptors.Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor.Binding, Thermodynamics, and Selectivity of a Non-peptide Antagonist to the Melanocortin-4 Receptor.Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors M1 and M2
P2860
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P2860
The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
The allosteric vestibule of a ...... or controls G-protein coupling
@ast
The allosteric vestibule of a ...... or controls G-protein coupling
@en
The allosteric vestibule of a ...... or controls G-protein coupling
@nl
type
label
The allosteric vestibule of a ...... or controls G-protein coupling
@ast
The allosteric vestibule of a ...... or controls G-protein coupling
@en
The allosteric vestibule of a ...... or controls G-protein coupling
@nl
prefLabel
The allosteric vestibule of a ...... or controls G-protein coupling
@ast
The allosteric vestibule of a ...... or controls G-protein coupling
@en
The allosteric vestibule of a ...... or controls G-protein coupling
@nl
P2093
P2860
P50
P356
P1476
The allosteric vestibule of a ...... or controls G-protein coupling
@en
P2093
Anke Müller
Anna Kebig
Carsten Hoffmann
Christian Tränkle
Evi Kostenis
Jasmin Schrobang-Ley
Jens Schmitz
Jessica Klöckner
Julia Bätz
Katharina Simon
P2860
P2888
P356
10.1038/NCOMMS2028
P407
P577
2012-01-01T00:00:00Z
P5875
P6179
1046138584