Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1. - Test2 - elhamkhani - TriplyDB

Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.

Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.

http://www.wikidata.org/entity/Q34300832

about

Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists Ebolavirus Evolution: Past and Present A Rapid Screening Assay Identifies Monotherapy with Interferon-ß and Combination Therapies with Nucleoside Analogs as Effective Inhibitors of Ebola Virus Nipah virus matrix protein: expert hacker of cellular machines.Targeting Importin-α7 as a Therapeutic Approach against Pandemic Influenza Viruses.The PDB database is a rich source of alpha-helical anti-microbial peptides to combat disease causing pathogens.Camouflage and misdirection: the full-on assault of ebola virus disease Human Ebola virus infection in West Africa: a review of available therapeutic agents that target different steps of the life cycle of Ebola virus.Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses.Elucidating variations in the nucleotide sequence of Ebola virus associated with increasing pathogenicity Characterizing alpha helical properties of Ebola viral proteins as potential targets for inhibition of alpha-helix mediated protein-protein interactions.A single phosphorodiamidate morpholino oligomer targeting VP24 protects rhesus monkeys against lethal Ebola virus infection Diversification of importin-α isoforms in cellular trafficking and disease states Innate immune evasion by filoviruses Possible FDA-approved drugs to treat Ebola virus infection Improving attrition rates in Ebola virus drug discovery.Ebolavirus classification based on natural vectors.Different Temporal Effects of Ebola Virus VP35 and VP24 Proteins on Global Gene Expression in Human Dendritic Cells.Assessing the contribution of interferon antagonism to the virulence of West African Ebola viruses Amino Acid Residue at Position 79 of Marburg Virus VP40 Confers Interferon Antagonism in Mouse Cells.Marburg Virus VP24 Protein Relieves Suppression of the NF-κB Pathway Through Interaction With Kelch-like ECH-Associated Protein 1.Importin-α7 Is Involved in the Formation of Ebola Virus Inclusion Bodies but Is Not Essential for Pathogenicity in Mice.Immunological features underlying viral hemorrhagic fevers Systematic Genome-wide Screening and Prediction of microRNAs in EBOV During the 2014 Ebolavirus Outbreak.Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells.STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways Predictive and comparative analysis of Ebolavirus proteins Changes associated with Ebola virus adaptation to novel species.Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion.Large-scale data-driven integrative framework for extracting essential targets and processes from disease-associated gene data sets.The Ebola virus VP35 protein binds viral immunostimulatory and host RNAs identified through deep sequencing Crystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression.Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins.Conserved differences in protein sequence determine the human pathogenicity of Ebolaviruses.DOCLASP - Docking ligands to target proteins using spatial and electrostatic congruence extracted from a known holoenzyme and applying simple geometrical transformations.New paradigms in sepsis: from prevention to protection of failing microcirculation.MSAViewer: interactive JavaScript visualization of multiple sequence alignments.Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses.Potential and emerging treatment options for Ebola virus disease.Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus

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P2860

Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.

http://www.wikidata.org/entity/Q34300832

description

2014 nî lūn-bûn

@nan

2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年學術文章

@yue

name

Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.

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Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.

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Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.

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Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.

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Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.

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Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.

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Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.

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Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.

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Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.

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J.CHOM.2014.07.008

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Cell Host & Microbe

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Ebola virus VP24 targets a uni ...... import of phosphorylated STAT1

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Alicia R Feagins

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Anuradha Mittal

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Benjamin Yen

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Daisy W Leung

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Gaya K Amarasinghe

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Joshua B Alinger

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Kayla N Berry

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Megan R Edwards

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Rohit V Pappu

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Tom J Brett

http://www.w3.org/2001/XMLSchema#string

P2860

Viral immune modulators perturb the human molecular network by common and unique strategies

Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA

Ebola haemorrhagic fever

PHENIX: a comprehensive Python-based system for macromolecular structure solution

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

Marburg Virus Evades Interferon Responses by a Mechanism Distinct from Ebola Virus

Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha

Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit

The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold

Crystal Structure of Marburg Virus VP24

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187-200

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10.1016/J.CHOM.2014.07.008

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2

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16

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Christopher F Basler

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2014-08-01T00:00:00Z

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264797593

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25121748

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phosphorylation

travel-associated infection

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4188415

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