Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.
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Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-AntagonistsEbolavirus Evolution: Past and PresentA Rapid Screening Assay Identifies Monotherapy with Interferon-ß and Combination Therapies with Nucleoside Analogs as Effective Inhibitors of Ebola VirusNipah virus matrix protein: expert hacker of cellular machines.Targeting Importin-α7 as a Therapeutic Approach against Pandemic Influenza Viruses.The PDB database is a rich source of alpha-helical anti-microbial peptides to combat disease causing pathogens.Camouflage and misdirection: the full-on assault of ebola virus diseaseHuman Ebola virus infection in West Africa: a review of available therapeutic agents that target different steps of the life cycle of Ebola virus.Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses.Elucidating variations in the nucleotide sequence of Ebola virus associated with increasing pathogenicityCharacterizing alpha helical properties of Ebola viral proteins as potential targets for inhibition of alpha-helix mediated protein-protein interactions.A single phosphorodiamidate morpholino oligomer targeting VP24 protects rhesus monkeys against lethal Ebola virus infectionDiversification of importin-α isoforms in cellular trafficking and disease statesInnate immune evasion by filovirusesPossible FDA-approved drugs to treat Ebola virus infectionImproving attrition rates in Ebola virus drug discovery.Ebolavirus classification based on natural vectors.Different Temporal Effects of Ebola Virus VP35 and VP24 Proteins on Global Gene Expression in Human Dendritic Cells.Assessing the contribution of interferon antagonism to the virulence of West African Ebola virusesAmino Acid Residue at Position 79 of Marburg Virus VP40 Confers Interferon Antagonism in Mouse Cells.Marburg Virus VP24 Protein Relieves Suppression of the NF-κB Pathway Through Interaction With Kelch-like ECH-Associated Protein 1.Importin-α7 Is Involved in the Formation of Ebola Virus Inclusion Bodies but Is Not Essential for Pathogenicity in Mice.Immunological features underlying viral hemorrhagic feversSystematic Genome-wide Screening and Prediction of microRNAs in EBOV During the 2014 Ebolavirus Outbreak.Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells.STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling PathwaysPredictive and comparative analysis of Ebolavirus proteinsChanges associated with Ebola virus adaptation to novel species.Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion.Large-scale data-driven integrative framework for extracting essential targets and processes from disease-associated gene data sets.The Ebola virus VP35 protein binds viral immunostimulatory and host RNAs identified through deep sequencingCrystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression.Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins.Conserved differences in protein sequence determine the human pathogenicity of Ebolaviruses.DOCLASP - Docking ligands to target proteins using spatial and electrostatic congruence extracted from a known holoenzyme and applying simple geometrical transformations.New paradigms in sepsis: from prevention to protection of failing microcirculation.MSAViewer: interactive JavaScript visualization of multiple sequence alignments.Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses.Potential and emerging treatment options for Ebola virus disease.Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus
P2860
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P2860
Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.
description
2014 nî lūn-bûn
@nan
2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
name
Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.
@ast
Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.
@en
Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.
@nl
type
label
Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.
@ast
Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.
@en
Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.
@nl
prefLabel
Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.
@ast
Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.
@en
Ebola virus VP24 targets a uni ...... mport of phosphorylated STAT1.
@nl
P2093
P2860
P50
P921
P1433
P1476
Ebola virus VP24 targets a uni ...... import of phosphorylated STAT1
@en
P2093
Alicia R Feagins
Anuradha Mittal
Benjamin Yen
Daisy W Leung
Gaya K Amarasinghe
Joshua B Alinger
Kayla N Berry
Megan R Edwards
Rohit V Pappu
Tom J Brett
P2860
P304
P356
10.1016/J.CHOM.2014.07.008
P577
2014-08-01T00:00:00Z