Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. - Test2 - elhamkhani - TriplyDB

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.

http://www.wikidata.org/entity/Q34301299

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Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?Nitroxide pharmaceutical development for age-related degeneration and disease Biochemical Genetic Pathways that Modulate Aging in Multiple Species Sirtuin 1 and aging theory for chronic obstructive pulmonary disease New insights into male (in)fertility: the importance of NO The role of free radicals in the aging brain and Parkinson's Disease: convergence and parallelism Essential Roles of Natural Products and Gaseous Mediators on Neuronal Cell Death or Survival NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2 Nuclear Factor-Erythroid-2-Related Factor 2 in Aging and Lung Fibrosis Stress-activated cap'n'collar transcription factors in aging and human disease Dietary antiaging phytochemicals and mechanisms associated with prolonged survival Aging and immune function: molecular mechanisms to interventions Nrf2-dysregulation correlates with reduced synthesis and low glutathione levels in experimental autoimmune encephalomyelitis Cardioprotective effect of paeonol and danshensu combination on isoproterenol-induced myocardial injury in rats Identification of age-specific Nrf2 binding to a novel antioxidant response element locus in the Gclc promoter: a compensatory means for the loss of glutathione synthetic capacity in the aging rat liver?Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity.An in vitro screening cascade to identify neuroprotective antioxidants in ALS Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription.Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response New Insights into the Pathogenesis of Alcohol-Induced ER Stress and Liver Diseases Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice.Genetic Variations and mRNA Expression of NRF2 in Parkinson's Disease.Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts.Zeaxanthin induces Nrf2-mediated phase II enzymes in protection of cell death.Kinetic characteristics of native gamma-glutamylcysteine ligase in the aging housefly, Musca domestica L Oxidative stress is associated with impaired arterial elasticity.NFE2L2 polymorphisms, mortality, and metabolism in the general population.Effect of glutathione redox state on Leydig cell susceptibility to acute oxidative stress.NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology.Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons.NRF2, cancer and calorie restriction Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake.Mechanisms of vascular aging: new perspectives.

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P2860

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.

http://www.wikidata.org/entity/Q34301299

description

2004 nî lūn-bûn

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2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2004 թվականի փետրվարին հրատարակված գիտական հոդված

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2004年の論文

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Decline in transcriptional act ...... s reversible with lipoic acid.

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Decline in transcriptional act ...... s reversible with lipoic acid.

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Decline in transcriptional act ...... s reversible with lipoic acid.

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Decline in transcriptional act ...... s reversible with lipoic acid.

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Decline in transcriptional act ...... s reversible with lipoic acid.

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Decline in transcriptional act ...... s reversible with lipoic acid.

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Decline in transcriptional act ...... s reversible with lipoic acid.

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Decline in transcriptional act ...... s reversible with lipoic acid.

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Decline in transcriptional act ...... s reversible with lipoic acid.

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Decline in transcriptional act ...... s reversible with lipoic acid.

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Anil K Jaiswal

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Brian M Dixon

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Honglei Liu

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Jung H Suh

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Rui-Ming Liu

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Swapna V Shenvi

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Tory M Hagen

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P2860

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues

Nrf2 is essential for protection against acute pulmonary injury in mice

An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

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10

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14985508

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