Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
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Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoformK-Cl cotransporters, cell volume homeostasis, and neurological diseaseCurrent view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2Domain-Swapping Switch Point in Ste20 Protein Kinase SPAKOverexpression of Ste20-related proline/alanine-rich kinase exacerbates experimental colitis in miceIRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathwayIdentification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lensesThe Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neuronsStructural and biochemical insights into the activation mechanisms of germinal center kinase OSR1.Behavioral analysis of Ste20 kinase SPAK knockout mice.Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.Ste20-related proline/alanine-rich kinase (SPAK) regulated transcriptionally by hyperosmolarity is involved in intestinal barrier function.Multiple pathways for protein phosphatase 1 (PP1) regulation of Na-K-2Cl cotransporter (NKCC1) function: the N-terminal tail of the Na-K-2Cl cotransporter serves as a regulatory scaffold for Ste20-related proline/alanine-rich kinase (SPAK) AND PP1.Chloride regulation in the pain pathwayDifferences in the large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4.Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling.On the substrate recognition and negative regulation of SPAK, a kinase modulating Na+-K+-2Cl- cotransport activityNADPH oxidase and PKC contribute to increased Na transport by the thick ascending limb during type 1 diabetesHypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule.Short forms of Ste20-related proline/alanine-rich kinase (SPAK) in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage.Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation.C. elegans STK39/SPAK ortholog-mediated inhibition of ClC anion channel activity is regulated by WNK-independent ERK kinase signalingSPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.SPAK-mediated NCC regulation in response to low-K+ dietDiscovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters.Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions.Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics.A noninvasive optical approach for assessing chloride extrusion activity of the K-Cl cotransporter KCC2 in neuronal cells.SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner.Calcium-binding protein 39 facilitates molecular interaction between Ste20p proline alanine-rich kinase and oxidative stress response 1 monomers.Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target.Inhibition of Na(+)-K(+)-2Cl(-) cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cellsRegulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.Multigene kinase network, kidney transport, and salt in essential hypertension.Nuclear factor-kappaB is a critical mediator of Ste20-like proline-/alanine-rich kinase regulation in intestinal inflammationThe Drosophila NKCC Ncc69 is required for normal renal tubule functionSte20-related proline/alanine-rich kinase: a novel regulator of intestinal inflammation.Kinase regulation of Na+-K+-2Cl- cotransport in primary afferent neurons.Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases.
P2860
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P2860
Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
@ast
Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
@en
Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
@nl
type
label
Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
@ast
Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
@en
Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
@nl
prefLabel
Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
@ast
Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
@en
Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
@nl
P2093
P2860
P1476
Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
@en
P2093
Eric Delpire
Kenneth B E Gagnon
Roger England
P2860
P304
P356
10.1128/MCB.26.2.689-698.2006
P407
P577
2006-01-01T00:00:00Z