Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling.
about
Regulators of G-protein signaling in the heart and their potential as therapeutic targets.Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins.FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.Regulator of G-protein signaling 18 controls both platelet generation and function.Development of a novel high-throughput screen and identification of small-molecule inhibitors of the Gα-RGS17 protein-protein interaction using AlphaScreen.The N-end rule pathway and regulation by proteolysisRegulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.Conformational dynamics of a regulator of G-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule.MicroRNAs that target RGS5.Altered expression and function of regulator of G-protein signaling-17 (RGS17) in hepatocellular carcinomaG protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesisRGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectivesEffects of acetylcholine and noradrenalin on action potentials of isolated rabbit sinoatrial and atrial myocytes.Cardiotonic steroids stabilize regulator of G protein signaling 2 protein levelsRGS10 Negatively Regulates Platelet Activation and Thrombogenesis.Pharmacological Modulation of the N-End Rule Pathway and Its Therapeutic Implications.Modulating platelet reactivity through control of RGS18 availability.Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell LinesRGS Proteins and Gαi2 Modulate Sleep, Wakefulness, and Disruption of Sleep/ Wake States after Isoflurane and Sevoflurane Anesthesia.Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity.A new non-canonical pathway of Gα(q) protein regulating mitochondrial dynamics and bioenergetics.NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growthDigoxin-Mediated Upregulation of RGS2 Protein Protects against Cardiac Injury.The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins.A physiologically required G protein-coupled receptor (GPCR)-regulator of G protein signaling (RGS) interaction that compartmentalizes RGS activity.Functional role, mechanisms of regulation, and therapeutic potential of regulator of G protein signaling 2 in the heart.G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function.Regulators of G protein signaling: role in hematopoiesis, megakaryopoiesis and platelet function.Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics.Embedded synaptic feedback in the neuroendocrine stress axis.Association of frequent genetic variants in platelet activation pathway genes with large-vessel ischemic stroke in Polish population.Small Molecule Inhibitors of Regulator of G Protein Signalling (RGS) ProteinsNeurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosine.Controlling Parasympathetic Regulation of Heart Rate: A Gatekeeper Role for RGS Proteins in the Sinoatrial Node.Effective Attenuation of Adenosine A1R Signaling by Neurabin Requires Oligomerization of Neurabin.Angiotensin II Type 1 Receptor Mechanoactivation Involves RGS5 (Regulator of G Protein Signaling 5) in Skeletal Muscle Arteries: Impaired Trafficking of RGS5 in Hypertension.Regulator of G Protein Signaling 6 Protects the Heart from Ischemic Injury.RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists
P2860
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P2860
Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Thinking outside of the "RGS b ...... lators of G protein signaling.
@ast
Thinking outside of the "RGS b ...... lators of G protein signaling.
@en
Thinking outside of the "RGS b ...... lators of G protein signaling.
@nl
type
label
Thinking outside of the "RGS b ...... lators of G protein signaling.
@ast
Thinking outside of the "RGS b ...... lators of G protein signaling.
@en
Thinking outside of the "RGS b ...... lators of G protein signaling.
@nl
prefLabel
Thinking outside of the "RGS b ...... lators of G protein signaling.
@ast
Thinking outside of the "RGS b ...... lators of G protein signaling.
@en
Thinking outside of the "RGS b ...... lators of G protein signaling.
@nl
P2860
P356
P1476
Thinking outside of the "RGS b ...... ulators of G protein signaling
@en
P2093
Benita Sjögren
P2860
P304
P356
10.1124/MOL.110.065219
P50
P577
2010-07-27T00:00:00Z