The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo. - Test2 - elhamkhani - TriplyDB

The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo.

The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo.

http://www.wikidata.org/entity/Q34310927

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Structure of precursor microRNA's terminal loop regulates human Dicer's dicing activity by switching DExH/D domain Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis Post-Translational Regulation of miRNA Pathway Components, AGO1 and HYL1, in Plants Bone Marrow Gene Therapy for HIV/AIDS Versatile microRNA biogenesis in animals and their viruses Ribonuclease III mechanisms of double-stranded RNA cleavage Genetic variants in microRNA genes: impact on microRNA expression, function, and disease A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer Structure of a Eukaryotic RNase III Postcleavage Complex Reveals a Double-Ruler Mechanism for Substrate Selection Transcriptome wide annotation of eukaryotic RNase III reactivity and degradation signals Organic small hairpin RNAs (OshR): a do-it-yourself platform for transgene-based gene silencing.The influence of the 5΄-terminal nucleotide on AgoshRNA activity and biogenesis: importance of the polymerase III transcription initiation site Genome-wide miRNA seeds prediction in Archaea.VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination.Small RNA sequence analysis of adenovirus VA RNA-derived miRNAs reveals an unexpected serotype-specific difference in structure and abundance Mammalian 5'-capped microRNA precursors that generate a single microRNA.A cytoplasmic RNA virus generates functional viral small RNAs and regulates viral IRES activity in mammalian cells Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs.PHDcleav: a SVM based method for predicting human Dicer cleavage sites using sequence and secondary structure of miRNA precursors.Comparative analysis of RNAi screening technologies at genome-scale reveals an inherent processing inefficiency of the plasmid-based shRNA hairpin Entropy-based model for miRNA isoform analysis.Development of gene therapy for treatment of age-related macular degeneration.Discovery of a dicer-independent, cell-type dependent alternate targeting sequence generator: implications in gene silencing & pooled RNAi screens.Synergistic inhibition of avian leukosis virus subgroup J replication by miRNA-embedded siRNA interference of double-target.A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs for broad applications.Sequence features of Drosha and Dicer cleavage sites affect the complexity of isomiRs High-throughput functional genomics using CRISPR-Cas9.Towards Antiviral shRNAs Based on the AgoshRNA Design.The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys.The host Integrator complex acts in transcription-independent maturation of herpesvirus microRNA 3' ends.MiRNA-Embedded ShRNAs for Radiation-Inducible LGMN Knockdown and the Antitumor Effects on Breast Cancer.The Menu of Features that Define Primary MicroRNAs and Enable De Novo Design of MicroRNA Genes.LBSizeCleav: improved support vector machine (SVM)-based prediction of Dicer cleavage sites using loop/bulge length.Ribozyme-enhanced single-stranded Ago2-processed interfering RNA triggers efficient gene silencing with fewer off-target effects A streamlined method for the design and cloning of shRNAs into an optimized Dox-inducible lentiviral vector.Prediction of potent shRNAs with a sequential classification algorithm.Nucleotide sequence of miRNA precursor contributes to cleavage site selection by Dicer.Expression profile of Epstein-Barr virus and human adenovirus small RNAs in tonsillar B and T lymphocytes.In vivo RNAi screens: concepts and applications.

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The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo.

http://www.wikidata.org/entity/Q34310927

description

2012 nî lūn-bûn

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2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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The loop position of shRNAs an ...... y of dicer processing in vivo.

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The loop position of shRNAs an ...... y of dicer processing in vivo.

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The loop position of shRNAs an ...... y of dicer processing in vivo.

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The loop position of shRNAs an ...... y of dicer processing in vivo.

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The loop position of shRNAs an ...... y of dicer processing in vivo.

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The loop position of shRNAs an ...... y of dicer processing in vivo.

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The loop position of shRNAs an ...... y of dicer processing in vivo.

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Lan Jin

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Mark A Kay

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P2860

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

Dicer recognizes the 5' end of RNA for efficient and accurate processing

Autoinhibition of human dicer by its internal helicase domain

Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

miRBase: integrating microRNA annotation and deep-sequencing data

Most mammalian mRNAs are conserved targets of microRNAs

Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2

Prediction of mammalian microRNA targets

Asymmetry in the assembly of the RNAi enzyme complex

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