Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy. - Test2 - elhamkhani - TriplyDB

Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy.

Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy.

http://www.wikidata.org/entity/Q34311339

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Future of seizure prediction and intervention: closing the loop Synthetic biology and therapeutic strategies for the degenerating brain: Synthetic biology approaches can transform classical cell and gene therapies, to provide new cures for neurodegenerative diseases Optogenetic delay of status epilepticus onset in an in vivo rodent epilepsy model Homeostasis or channelopathy? Acquired cell type-specific ion channel changes in temporal lobe epilepsy and their antiepileptic potential Optogenetic tools for modulating and probing the epileptic network Changing channels in pain and epilepsy: Exploiting ion channel gene therapy for disorders of neuronal hyperexcitability Therapeutic potential of optogenetic neuromodulation Epilepsy priorities in Europe: A report of the ILAE-IBE Epilepsy Advocacy Europe Task Force One Site to Rule Them All: Toward a Master Regulator of Ictal Activity.A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period.On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy.Ictal high frequency oscillations distinguish two types of seizure territories in humans Closed-loop optogenetic intervention in mice.Clinical, genetic, neurophysiological and functional study of new mutations in episodic ataxia type 1.Spatiotemporal dynamics of optogenetically induced and spontaneous seizure transitions in primary generalized epilepsy.Chemical-genetic attenuation of focal neocortical seizures.The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy.Gene and cell therapy for children--new medicines, new challenges?A channelopathy mutation in the voltage-sensor discloses contributions of a conserved phenylalanine to gating properties of Kv1.1 channels and ataxia Deep brain stimulation for the treatment of epilepsy: circuits, targets, and trials.RNA editing in the central cavity as a mechanism to regulate surface expression of the voltage-gated potassium channel Kv1.1.Gene therapy in status epilepticus.Voltage-gated potassium channels at the crossroads of neuronal function, ischemic tolerance, and neurodegeneration.Gene therapy in epilepsy-is it time for clinical trials?Real-time in vivo optogenetic neuromodulation and multielectrode electrophysiologic recording with NeuroRighter.Beyond the hammer and the scalpel: selective circuit control for the epilepsies Seizure suppression by high frequency optogenetic stimulation using in vitro and in vivo animal models of epilepsy Cerebellar Directed Optogenetic Intervention Inhibits Spontaneous Hippocampal Seizures in a Mouse Model of Temporal Lobe Epilepsy.[New aspects in the field of epilepsy].An organotypic brain slice preparation from adult patients with temporal lobe epilepsy Seizure reduction through interneuron-mediated entrainment using low frequency optical stimulation.Inappropriate Neural Activity during a Sensitive Period in Embryogenesis Results in Persistent Seizure-like Behavior.Analysis of Proteins That Rapidly Change Upon Mechanistic/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC)Seizing Control: From Current Treatments to Optogenetic Interventions in Epilepsy How might novel technologies such as optogenetics lead to better treatments in epilepsy?Organization and control of epileptic circuits in temporal lobe epilepsy.Overexpression of adenosine kinase in cortical astrocytes and focal neocortical epilepsy in mice Progress in gene therapy for neurological disorders.Channelrhodopsins: visual regeneration and neural activation by a light switch.

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Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy.

http://www.wikidata.org/entity/Q34311339

description

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Optogenetic and potassium chan ...... of focal neocortical epilepsy.

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Optogenetic and potassium chan ...... of focal neocortical epilepsy.

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Optogenetic and potassium chan ...... of focal neocortical epilepsy.

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Optogenetic and potassium chan ...... of focal neocortical epilepsy.

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Science Translational Medicine

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Optogenetic and potassium chan ...... of focal neocortical epilepsy.

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Kevan S Hashemi

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Laura Mantoan

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P2860

Identification of new epilepsy treatments: issues in preclinical methodology

Optogenetic control of epileptiform activity

Multimodal fast optical interrogation of neural circuitry

Presurgical evaluation of epilepsy

The self-tuning neuron: synaptic scaling of excitatory synapses

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons.

Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures.

Image-guided convection-enhanced delivery of muscimol to the primate brain

Increased pyramidal excitability and NMDA conductance can explain posttraumatic epileptogenesis without disinhibition: a model.

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Dimitri Kullmann

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