Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities.
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Biophysical and computational methods to analyze amino acid interaction networks in proteinsExploring the role of receptor flexibility in structure-based drug discoveryStructure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewGaussian Accelerated Molecular Dynamics: Unconstrained Enhanced Sampling and Free Energy CalculationUsing modern tools to probe the structure-function relationship of fatty acid synthasesTargeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effectsCorrelated motions and residual frustration in thrombin.Emerging Computational Methods for the Rational Discovery of Allosteric Drugs.Allosteric regulation of the Hsp90 dynamics and stability by client recruiter cochaperones: protein structure network modelingComputational modeling of allosteric regulation in the hsp90 chaperones: a statistical ensemble analysis of protein structure networks and allosteric communications.Kinesin-5 allosteric inhibitors uncouple the dynamics of nucleotide, microtubule, and neck-linker binding sites.Structure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.Accelerated molecular dynamics simulations of ligand binding to a muscarinic G-protein-coupled receptor.Detecting Allosteric Networks Using Molecular Dynamics SimulationImproved Reweighting of Accelerated Molecular Dynamics Simulations for Free Energy Calculation.Thrombomodulin Binding Selects the Catalytically Active Form of ThrombinIdentifying Allosteric Hotspots with Dynamics: Application to Inter- and Intra-species ConservationA mechanistic understanding of allosteric immune escape pathways in the HIV-1 envelope glycoprotein.Two pathways mediate interdomain allosteric regulation in pin1NbIT--a new information theory-based analysis of allosteric mechanisms reveals residues that underlie function in the leucine transporter LeuT.Accelerated molecular dynamics simulations of protein folding.Computational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled ReceptorsDabigatran and Argatroban Diametrically Modulate Thrombin Exosite FunctionAllosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile.AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems.Ligand binding to anion-binding exosites regulates conformational properties of thrombin.Dynamic Coupling and Allosteric Networks in the α Subunit of Heterotrimeric G Proteins.Dynamical network of residue-residue contacts reveals coupled allosteric effects in recognition, catalysis, and mutation.Computational approaches to detect allosteric pathways in transmembrane molecular machines.Activation and dynamic network of the M2 muscarinic receptor.Protein Allostery and Conformational Dynamics.Mapping the structural and dynamical features of kinesin motor domainsUnidirectional allostery in the regulatory subunit RIα facilitates efficient deactivation of protein kinase A.The spatial structure of cell signaling systems.NMR reveals a dynamic allosteric pathway in thrombin.Weighted Implementation of Suboptimal Paths (WISP): An Optimized Algorithm and Tool for Dynamical Network Analysis.Free energy landscape of G-protein coupled receptors, explored by accelerated molecular dynamicsGeneral trends of dihedral conformational transitions in a globular protein.Local packing modulates diversity of iron pathways and cooperative behavior in eukaryotic and prokaryotic ferritins.Measuring dynamic and kinetic information in the previously inaccessible supra-τ(c) window of nanoseconds to microseconds by solution NMR spectroscopy.
P2860
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P2860
Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities.
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities.
@ast
Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities.
@en
Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities.
@nl
type
label
Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities.
@ast
Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities.
@en
Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities.
@nl
prefLabel
Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities.
@ast
Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities.
@en
Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities.
@nl
P2093
P2860
P356
P1476
Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities.
@en
P2093
Brian Fuglestad
Elizabeth A Komives
Paul M Gasper
Phineus R L Markwick
P2860
P304
21216-21222
P356
10.1073/PNAS.1218414109
P407
P577
2012-11-28T00:00:00Z