Hyperinsulinemia drives diet-induced obesity independently of brain insulin production. - Test2 - elhamkhani - TriplyDB

Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.

Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.

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Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans Insulin regulates brain function, but how does it get there?High-fat diet impairs spatial memory and hippocampal intrinsic excitability and sex-dependently alters circulating insulin and hippocampal insulin sensitivity GLUT4 defects in adipose tissue are early signs of metabolic alterations in Alms1GT/GT, a mouse model for obesity and insulin resistance Questioning the preclinical paradigm: natural, extreme biology as an alternative discovery platform CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice High-content screening identifies a role for Na(+) channels in insulin production Islet Hypersensitivity to Glucose Is Associated With Disrupted Oscillations and Increased Impact of Proinflammatory Cytokines in Islets From Diabetes-Prone Male Mice.Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice.A small amount of dietary carbohydrate can promote the HFD-induced insulin resistance to a maximal level Leucine facilitates insulin signaling through a Gαi protein-dependent signaling pathway in hepatocytes.Is dynamic autocrine insulin signaling possible? A mathematical model predicts picomolar concentrations of extracellular monomeric insulin within human pancreatic islets.Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation.Deficiency of oncostatin M receptor β (OSMRβ) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice.Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer's Disease.Multiparameter screening reveals a role for Na+ channels in cytokine-induced β-cell death.Cellular insulin resistance disrupts leptin-mediated control of neuronal signaling and transcription.Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice.Dopamine D2 receptors and the circadian clock reciprocally mediate antipsychotic drug-induced metabolic disturbances.Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.Insulin action in brain regulates systemic metabolism and brain function.Carbohydrate modified diet & insulin sensitizers reduce body weight & modulate metabolic syndrome measures in EMPOWIR (enhance the metabolic profile of women with insulin resistance): a randomized trial of normoglycemic women with midlife weight gai Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes.Mechanisms of insulin resistance in obesity Modeling type 2 diabetes in rats using high fat diet and streptozotocin.Effect of a low-starch/low-dairy diet on fat oxidation in overweight and obese women with polycystic ovary syndrome.Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges.Effects of insulin on human pancreatic cancer progression modeled in vitro Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity.Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells.Fetal hyperglycemia and a high-fat diet contribute to aberrant glucose tolerance and hematopoiesis in adult rats.Ins1(Cre) knock-in mice for beta cell-specific gene recombination.Altered pancreatic growth and insulin secretion in WSB/EiJ mice.High-fat diet-induced adiposity, adipose inflammation, hepatic steatosis and hyperinsulinemia in outbred CD-1 mice.A practical guide to genetic engineering of pancreatic β-cells in vivo: getting a grip on RIP and MIP.A live-cell, high-content imaging survey of 206 endogenous factors across five stress conditions reveals context-dependent survival effects in mouse primary beta cells.Impact of Gender on the Association of Epicardial Fat Thickness, Obesity, and Circadian Blood Pressure Pattern in Hypertensive Patients Increased Specific Labeling of INS-1 Pancreatic Beta-Cell by Using RIP-Driven Cre Mutants with Reduced Activity

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Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.

http://www.wikidata.org/entity/Q34315893

description

2012 nî lūn-bûn

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2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.

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Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.

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Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.

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type

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Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.

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Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.

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Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.

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prefLabel

Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.

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Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.

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Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.

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J.CMET.2012.10.019

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Cell Metabolism

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Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.

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Ali Asadi

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Arya E Mehran

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Bradford G Hoffman

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G Stefano Brigidi

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James D Johnson

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Kwan-Yi Chu

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Nicole M Templeman

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Shernaz X Bamji

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scholarly article

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10.1016/J.CMET.2012.10.019

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Timothy J Kieffer

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2012-12-01T00:00:00Z

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