The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.
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Landmarks in insulin researchAlanine scanning of a putative receptor binding surface of insulin-like growth factor-IHarmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activationDesign of an Active Ultrastable Single-chain Insulin Analog: SYNTHESIS, STRUCTURE, AND THERAPEUTIC IMPLICATIONSStructural and Biological Properties of the Drosophila Insulin-like Peptide 5 Show Evolutionary ConservationNovel Covalently Linked Insulin Dimer Engineered to Investigate the Function of Insulin DimerizationCrystal structure of the first three domains of the type-1 insulin-like growth factor receptorSystematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analoguesContribution of TyrB26 to the Function and Stability of Insulin: STRUCTURE-ACTIVITY RELATIONSHIPS AT A CONSERVED HORMONE-RECEPTOR INTERFACE.Insulin/receptor binding: the last piece of the puzzle? What recent progress on the structure of the insulin/receptor complex tells us (or not) about negative cooperativity and activation.A comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information.Pharmacomimetics of exercise: novel approaches for hippocampally-targeted neuroprotective agents.IL-6 type cytokine receptor complexes: hexamer, tetramer or both?Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.Insulin-like growth factors I and II receptors in the breast cancer survival disparity among African-American women.Mechanisms of activation of receptor tyrosine kinases: monomers or dimers.Synchronization in G0/G1 enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin.Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells.Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms.Risk factors for breast cancer and expression of insulin-like growth factor-2 (IGF-2) in women with breast cancer in Wuhan City, China.Logical analysis of timing-dependent receptor signalling specificity: application to the insulin receptor metabolic and mitogenic signalling pathways.Genetic engineering in mice: impact on insulin signalling and action.Agonism and antagonism at the insulin receptor.Structure of the insulin receptor ectodomain reveals a folded-over conformation.Flexibility in the insulin receptor ectodomain enables docking of insulin in crystallographic conformation observed in a hormone-bound microreceptor.An overview of insulin glargine.Assembly of high-affinity insulin receptor agonists and antagonists from peptide building blocksInsulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin receptor tyrosine kinase domain.Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II.Mechanistic diversity of cytokine receptor signaling across cell membranes.Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates.Specific binding of proinsulin C-peptide to human cell membranes.Characterization of ligand binding of a soluble human insulin-like growth factor I receptor variant suggests a ligand-induced conformational change.Diabetes mellitus due to the toxic misfolding of proinsulin variants.Ligand-induced ErbB receptor dimerization.Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells.Insulin: a small protein with a long journey.Glucose metabolism disorders and the risk of cancer.Radioligand dissociation measurements: potential interference of rebinding and allosteric mechanisms and physiological relevance of the biological model systems.The IGF-1 receptor and regulation of nitric oxide bioavailability and insulin signalling in the endothelium.
P2860
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P2860
The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.
description
1994 nî lūn-bûn
@nan
1994 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
The structural basis of insuli ...... c versus metabolic signalling.
@ast
The structural basis of insuli ...... c versus metabolic signalling.
@en
The structural basis of insuli ...... c versus metabolic signalling.
@nl
type
label
The structural basis of insuli ...... c versus metabolic signalling.
@ast
The structural basis of insuli ...... c versus metabolic signalling.
@en
The structural basis of insuli ...... c versus metabolic signalling.
@nl
prefLabel
The structural basis of insuli ...... c versus metabolic signalling.
@ast
The structural basis of insuli ...... c versus metabolic signalling.
@en
The structural basis of insuli ...... c versus metabolic signalling.
@nl
P356
P1433
P1476
The structural basis of insuli ...... ic versus metabolic signalling
@en
P2093
P De Meyts
P2888
P304
P356
10.1007/BF00400837
P478
37 Suppl 2
P577
1994-09-01T00:00:00Z
P6179
1004218537