The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. - Test2 - elhamkhani - TriplyDB

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

http://www.wikidata.org/entity/Q34321233

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Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization Mechanisms of Hippo pathway regulation The Non-Canonical Role of Aurora-A in DNA Replication A Cell Biologist's Field Guide to Aurora Kinase Inhibitors Selective Aurora Kinase Inhibitors Identified Using a Taxol-Induced Checkpoint Sensitivity Screen Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2 The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1 Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.Tumor suppressor NF2/Merlin is a microtubule stabilizer.KIBRA: In the brain and beyond LATS2 is de-methylated and overexpressed in nasopharyngeal carcinoma and predicts poor prognosis.Aurora kinase A is not involved in CPEB1 phosphorylation and cyclin B1 mRNA polyadenylation during meiotic maturation of porcine oocytes A novel cell-based, high-content assay for phosphorylation of Lats2 by Aurora A.The aurora kinases in cell cycle and leukemia The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1 Aurora A kinase modulates actin cytoskeleton through phosphorylation of Cofilin: Implication in the mitotic process.NDR kinases regulate essential cell processes from yeast to humans.Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest p53: guardian of ploidy KIBRA protein phosphorylation is regulated by mitotic kinase aurora and protein phosphatase 1.Aberrant large tumor suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas.A functional cooperativity between Aurora A kinase and LIM kinase1: implication in the mitotic process AIBp regulates mitotic entry and mitotic spindle assembly by controlling activation of both Aurora-A and Plk1.Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B.KIBRA regulates aurora kinase activity and is required for precise chromosome alignment during mitosis.Warts phosphorylates mud to promote pins-mediated mitotic spindle orientation in Drosophila, independent of Yorkie.Down-regulation of LATS kinases alters p53 to promote cell migration.The mob as tumor suppressor gene is essential for early development and regulates tissue growth in Drosophila.Aurora A kinase (AURKA) in normal and pathological cell division.Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk.A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability Aurora kinase inhibitors: identification and preclinical validation of their biomarkers.CDK1 phosphorylation of YAP promotes mitotic defects and cell motility and is essential for neoplastic transformation.Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation.Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins.

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The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

http://www.wikidata.org/entity/Q34321233

description

2004 nî lūn-bûn

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2004 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2004 թվականի մայիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

@ast

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

@en

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

@nl

type

label

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

@ast

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

@en

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

@nl

prefLabel

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

@ast

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

@en

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

@nl

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J.1356-9597.2004.00732.X

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P1476

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase

@en

P2093

Hiroshi Nojima

http://www.w3.org/2001/XMLSchema#string

Norikazu Yabuta

http://www.w3.org/2001/XMLSchema#string

Shingo Toji

http://www.w3.org/2001/XMLSchema#string

Souichi Nishihara

http://www.w3.org/2001/XMLSchema#string

Susumu Suzuki

http://www.w3.org/2001/XMLSchema#string

Toshiko Kobayashi

http://www.w3.org/2001/XMLSchema#string

Toshiya Hosomi

http://www.w3.org/2001/XMLSchema#string

P2860

Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity

Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs

A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts

Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor

Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor

Lats2, a putative tumor suppressor, inhibits G1/S transition

HsMCM6: a new member of the human MCM/P1 family encodes a protein homologous to fission yeast Mis5

Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

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383-397

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5

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9

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Katsuyuki Tamai

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2004-05-01T00:00:00Z

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8559434

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15147269

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phosphorylation