Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.

Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.

Item
http://www.wikidata.org/entity/Q34325540
Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in miceRole of LRRK2 in the regulation of dopamine receptor traffickingLRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit functionThe function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice.Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in micePAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.Abnormal visual gain control and excitotoxicity in early-onset Parkinson's disease Drosophila models.Targeted kinase inhibition relieves slowness and tremor in a Drosophila model of LRRK2 Parkinson's disease.Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson's disease.Prediction and characterization of human ageing-related proteins by using machine learning.Small-Molecule Inhibitors of LRRK2.Overexpression of Wild-Type Human Alpha-Synuclein Causes Metabolism Abnormalities in Thy1-aSYN Transgenic Mice
P2860

Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.

Item
http://www.wikidata.org/entity/Q34325540
description
2014 nî lūn-bûn
@nan
2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Genetic and pharmacological ev ...... decline associated with aging.
@ast
Genetic and pharmacological ev ...... decline associated with aging.
@en
Genetic and pharmacological ev ...... decline associated with aging.
@nl
type
label
Genetic and pharmacological ev ...... decline associated with aging.
@ast
Genetic and pharmacological ev ...... decline associated with aging.
@en
Genetic and pharmacological ev ...... decline associated with aging.
@nl
prefLabel
Genetic and pharmacological ev ...... decline associated with aging.
@ast
Genetic and pharmacological ev ...... decline associated with aging.
@en
Genetic and pharmacological ev ...... decline associated with aging.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P478
P50
P577
P5875
P698
P921
P932
P356
P1433
P1476
Genetic and pharmacological ev ...... decline associated with aging.
@en
P2093
P2860
P304
P31
P356
P478
P50
P577
P5875
P698
P921
P932