Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity.
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Evaluation of database-derived pathway development for enabling biomarker discovery for hepatotoxicityTimosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters.Modeling of Hepatocytes Proliferation Isolated from Proximal and Distal Zones from Human Hepatocellular Carcinoma Lesion.Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes.Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury.Cell sources for in vitro human liver cell culture models.Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: A novel in vitro cholestatic model.An evaluation of the latest in vitro tools for drug metabolism studies.Competency of different cell models to predict human hepatotoxic drugs.Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.Transport-Metabolism Interplay of Atazanavir in Rat Hepatocytes.3D Cultivation Techniques for Primary Human Hepatocytes.Drug Transporter Expression and Activity in Human Hepatoma HuH-7 Cells.Clinical translation of bioartificial liver support systems with human pluripotent stem cell-derived hepatic cells.Cellular Models and In Vitro Assays for the Screening of modulators of P-gp, MRP1 and BCRP.Long-term culture of primary hepatocytes: new matrices and microfluidic devices.Verapamil hepatic clearance in four preclinical rat models: towards activity-based scaling.Use of Thymidine Kinase Recombinant Adenovirus and Ganciclovir Mediated Mouse Liver Preconditioning for Hepatocyte Xenotransplantation.Establishment and assessment of a novel in vitro bio-PK/PD system in predicting the in vivo pharmacokinetics and pharmacodynamics of cyclophosphamide.Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.Bile canaliculi formation and biliary transport in 3D sandwich-cultured hepatocytes in dependence of the extracellular matrix composition.Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: A multi-center study.New physiologically-relevant liver tissue model based on hierarchically cocultured primary rat hepatocytes with liver endothelial cells.Current Concepts in Drug-Induced Bile Salt Export Pump (BSEP) Interference.Hepatobiliary and intestinal elimination of darunavir in an integrated preclinical rat model.Sandwich-cultured rat hepatocytes as an in vitro model to study canalicular transport alterations in cholestasis
P2860
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P2860
Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity.
description
2013 nî lūn-bûn
@nan
2013 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մարտին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Sandwich-cultured hepatocytes: ...... d drug-induced hepatotoxicity.
@ast
Sandwich-cultured hepatocytes: ...... d drug-induced hepatotoxicity.
@en
Sandwich-cultured hepatocytes: ...... d drug-induced hepatotoxicity.
@nl
type
label
Sandwich-cultured hepatocytes: ...... d drug-induced hepatotoxicity.
@ast
Sandwich-cultured hepatocytes: ...... d drug-induced hepatotoxicity.
@en
Sandwich-cultured hepatocytes: ...... d drug-induced hepatotoxicity.
@nl
prefLabel
Sandwich-cultured hepatocytes: ...... d drug-induced hepatotoxicity.
@ast
Sandwich-cultured hepatocytes: ...... d drug-induced hepatotoxicity.
@en
Sandwich-cultured hepatocytes: ...... d drug-induced hepatotoxicity.
@nl
P2093
P2860
P1476
Sandwich-cultured hepatocytes: ...... d drug-induced hepatotoxicity.
@en
P2093
Janneke Keemink
Johan Nicolaï
Pieter Annaert
Sagnik Chatterjee
Sarinj Fattah
Tom De Bruyn
P2860
P304
P356
10.1517/17425255.2013.773973
P407
P577
2013-03-02T00:00:00Z