Discovery of a novel selective kappa-opioid receptor agonist using crystal structure-based virtual screening.
about
Structure-based discovery of opioid analgesics with reduced side effects.The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonistStructure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid ReceptorStructure-based virtual screening of the nociceptin receptor: hybrid docking and shape-based approaches for improved hit identification.The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor.Discovery of GPCR ligands for probing signal transduction pathways.Molecular docking screening using agonist-bound GPCR structures: probing the A2A adenosine receptor.Opioid receptors: Structural and mechanistic insights into pharmacology and signaling.Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors.Muscarinic receptors as model targets and antitargets for structure-based ligand discovery.Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at κ-opioid receptors in striatal neurons.Chemotype-selective modes of action of κ-opioid receptor agonists.Does the kappa opioid receptor system contribute to pain aversion?New Technologies for Elucidating Opioid Receptor Function.Identifying ligands at orphan GPCRs: current status using structure-based approaches.Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor.Discovery of new GPCR ligands to illuminate new biology.D4 dopamine receptor high-resolution structures enable the discovery of selective agonists.GPCRs: What Can We Learn from Molecular Dynamics Simulations?Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor.LBVS: an online platform for ligand-based virtual screening using publicly accessible databases.
P2860
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P2860
Discovery of a novel selective kappa-opioid receptor agonist using crystal structure-based virtual screening.
description
2013 nî lūn-bûn
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2013 թուականի Մարտին հրատարակուած գիտական յօդուած
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2013 թվականի մարտին հրատարակված գիտական հոդված
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2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年學術文章
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name
Discovery of a novel selective ...... cture-based virtual screening.
@ast
Discovery of a novel selective ...... cture-based virtual screening.
@en
Discovery of a novel selective ...... cture-based virtual screening.
@nl
type
label
Discovery of a novel selective ...... cture-based virtual screening.
@ast
Discovery of a novel selective ...... cture-based virtual screening.
@en
Discovery of a novel selective ...... cture-based virtual screening.
@nl
prefLabel
Discovery of a novel selective ...... cture-based virtual screening.
@ast
Discovery of a novel selective ...... cture-based virtual screening.
@en
Discovery of a novel selective ...... cture-based virtual screening.
@nl
P2093
P2860
P50
P356
P1476
Discovery of a novel selective ...... cture-based virtual screening.
@en
P2093
Michael J Caspers
Thomas E Prisinzano
P2860
P304
P356
10.1021/CI400019T
P577
2013-03-13T00:00:00Z