Proteasome inhibitors: from research tools to drug candidates.
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The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic inventionThe ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradationAutoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugatesAPC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathwayInhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisonsMapping and structural dissection of human 20 S proteasome using proteomic approachesNrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3Ubiquitin-proteasome system as a modulator of cell fateDocking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entrySelective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitroProteasome inhibitors: their effects on arachidonic acid release from cells in culture and arachidonic acid metabolism in rat liver cellsDevelopment of a method for screening short-lived proteins using green fluorescent proteinHistone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells.Mechanical Signaling in the Pathophysiology of Critical Illness MyopathyProteomics in Traditional Chinese Medicine with an Emphasis on Alzheimer's DiseaseRegulation of the proteasome by ATP: implications for ischemic myocardial injury and donor heart preservationA method to rapidly create protein aggregates in living cells.Structural Analysis of Spiro β-Lactone Proteasome InhibitorsInhibitors selective for mycobacterial versus human proteasomesCharacterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunitOmuralide and vibralactone: differences in the proteasome- β-lactone-γ-lactam binding scaffold alter target preferencesAn inducible chaperone adapts proteasome assembly to stress.Proteasome inhibitors disrupt the unfolded protein response in myeloma cellsDissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatinOverexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibitionBortezomib is cytotoxic to the human growth plate and permanently impairs bone growth in young miceMyotonia congenita mutation enhances the degradation of human CLC-1 chloride channelsMycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificityIdentification of substrates of the Mycobacterium tuberculosis proteasomeThe ubiquitin proteasome system plays a role in venezuelan equine encephalitis virus infectionRegulating a Post-Transcriptional Regulator: Protein Phosphorylation, Degradation and Translational Blockage in Control of the Trypanosome Stress-Response RNA-Binding Protein ZC3H11Cross-talk between lipid and protein carbonylation in a dynamic cardiomyocyte model of mild nitroxidative stressHeat shock protein responses to aging and proteotoxicity in the olfactory bulb.Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner.Evidence for dynein and astral microtubule-mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cellsPurification of the Arabidopsis 26 S proteasome: biochemical and molecular analyses revealed the presence of multiple isoforms.The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.Identification of a peptoid inhibitor of the proteasome 19S regulatory particle.Role of proteasomes in disease.Role of the ubiquitin system and tumor viruses in AIDS-related cancer.
P2860
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P2860
Proteasome inhibitors: from research tools to drug candidates.
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Proteasome inhibitors: from research tools to drug candidates.
@ast
Proteasome inhibitors: from research tools to drug candidates.
@en
Proteasome inhibitors: from research tools to drug candidates.
@nl
type
label
Proteasome inhibitors: from research tools to drug candidates.
@ast
Proteasome inhibitors: from research tools to drug candidates.
@en
Proteasome inhibitors: from research tools to drug candidates.
@nl
prefLabel
Proteasome inhibitors: from research tools to drug candidates.
@ast
Proteasome inhibitors: from research tools to drug candidates.
@en
Proteasome inhibitors: from research tools to drug candidates.
@nl
P1476
Proteasome inhibitors: from research tools to drug candidates.
@en
P2093
Goldberg AL
Kisselev AF
P304
P356
10.1016/S1074-5521(01)00056-4
P577
2001-08-01T00:00:00Z