BET bromodomains mediate transcriptional pause release in heart failure - Test2 - elhamkhani - TriplyDB

BET bromodomains mediate transcriptional pause release in heart failure

BET bromodomains mediate transcriptional pause release in heart failure

http://www.wikidata.org/entity/Q34361491

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Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release Epigenetics and inheritance of phenotype variation in livestock Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies The bromodomain: from epigenome reader to druggable target Clinical applications of epigenetics in cardiovascular disease: the long road ahead Epigenetic polypharmacology: from combination therapy to multitargeted drugs H2A.Z: a molecular rheostat for transcriptional control Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes Acetyl-lysine erasers and readers in the control of pulmonary hypertension and right ventricular hypertrophy The mechanisms behind the therapeutic activity of BET bromodomain inhibition Functions of BET proteins in erythroid gene expression Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery Open access target validation is a more efficient way to accelerate drug discovery Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4 expression DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation Drug Discovery Targeting Bromodomain-Containing Protein 4.The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network.Histone cross-talk connects protein phosphatase 1α (PP1α) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression.Epigenetic mechanisms in heart failure pathogenesis Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease.Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA.Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells.Readers, writers, and erasers: chromatin as the whiteboard of heart disease Roles and post-translational regulation of cardiac class IIa histone deacetylase isoforms.CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle.Bromodomain inhibitors regulate the C9ORF72 locus in ALS Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure.GC skew defines distinct RNA polymerase pause sites in CpG island promoters.BET protein inhibition mitigates acute myocardial infarction damage in rats via the TLR4/TRAF6/NF-κB pathway BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones.BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries.Differential role of an NF-κB transcriptional response element in endothelial versus intimal cell VCAM-1 expression.It's Time for An Epigenomics Roadmap of Heart Failure BET Bromodomain Suppression Inhibits VEGF-induced Angiogenesis and Vascular Permeability by Blocking VEGFR2-mediated Activation of PAK1 and eNOS Btg2 is a Negative Regulator of Cardiomyocyte Hypertrophy through a Decrease in Cytosolic RNA.Epigenetic regulation in heart failure.Inhibition of BET proteins impairs estrogen-mediated growth and transcription in breast cancers by pausing RNA polymerase advancement.Erythropoiesis provides a BRD's eye view of BET protein function.

P2860

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P2860

BET bromodomains mediate transcriptional pause release in heart failure

http://www.wikidata.org/entity/Q34361491

description

2013 nî lūn-bûn

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2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի օգոստոսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

BET bromodomains mediate transcriptional pause release in heart failure

@ast

BET bromodomains mediate transcriptional pause release in heart failure

@en

BET bromodomains mediate transcriptional pause release in heart failure

@nl

type

label

BET bromodomains mediate transcriptional pause release in heart failure

@ast

BET bromodomains mediate transcriptional pause release in heart failure

@en

BET bromodomains mediate transcriptional pause release in heart failure

@nl

prefLabel

BET bromodomains mediate transcriptional pause release in heart failure

@ast

BET bromodomains mediate transcriptional pause release in heart failure

@en

BET bromodomains mediate transcriptional pause release in heart failure

@nl

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J.CELL.2013.07.013

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P1476

BET bromodomains mediate transcriptional pause release in heart failure

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Charles Y Lin

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Jace Bullard

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James E Bradner

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Jonathan D Brown

http://www.w3.org/2001/XMLSchema#string

Jorge Plutzky

http://www.w3.org/2001/XMLSchema#string

Jun Qi

http://www.w3.org/2001/XMLSchema#string

Kareem Alazem

http://www.w3.org/2001/XMLSchema#string

Kenneth B Margulies

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M Amer Alaiti

http://www.w3.org/2001/XMLSchema#string

Pedro Calderon Artero

http://www.w3.org/2001/XMLSchema#string

P2860

Executive Summary: Heart Disease and Stroke Statistics--2012 Update: A Report From the American Heart Association

Selective inhibition of BET bromodomains

Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells

Histone recognition and large-scale structural analysis of the human bromodomain family

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Small-molecule inhibition of BRDT for male contraception.

c-Myc regulates transcriptional pause release

Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals

Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription

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Madeleine Lemieux

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