Relating repair susceptibility of carcinogen-damaged DNA with structural distortion and thermodynamic stability
about
Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouseNucleotide excision repair efficiencies of bulky carcinogen-DNA adducts are governed by a balance between stabilizing and destabilizing interactionsSimulating structural and thermodynamic properties of carcinogen-damaged DNA.Intercalative conformations of the 14R (+)- and 14S (-)-trans-anti-DB[a,l]P-N⁶-dA adducts: molecular modeling and MD simulations.Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery.Synthesis of oligonucleotides containing the N2-deoxyguanosine adduct of the dietary carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline.Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic featuresHMGB1 interacts with XPA to facilitate the processing of DNA interstrand crosslinks in human cells.Dynamic conformational heterogeneities of carcinogen-DNA adducts and their mutagenic relevance.Conformational searches elucidate effects of stereochemistry on structures of deoxyadenosine covalently bound to tumorigenic metabolites of benzo[C] phenanthrene.Regulation and disregulation of mammalian nucleotide excision repair: a pathway to nongermline breast carcinogenesis.Influence of structural and functional modifications of selected genotoxic carcinogens on metabolism and mutagenicity - a review.DNA adduct structure-function relationships: comparing solution with polymerase structures.Effects of benzo(e)pyrene on the retinal neurosensory cells and human microvascular endothelial cells in vitro.Human RNA polymerase II is partially blocked by DNA adducts derived from tumorigenic benzo[c]phenanthrene diol epoxides: relating biological consequences to conformational preferences.Base damage, local sequence context and TP53 mutation hotspots: a molecular dynamics study of benzo[a]pyrene induced DNA distortion and mutabilityGeneration, repair and replication of guanine oxidation products.Accommodation of a 1S-(-)-benzo[c]phenanthrenyl-N6-dA adduct in the Y-family Dpo4 DNA polymerase active site: structural insights through molecular dynamics simulations.Dynamics of a benzo[a]pyrene-derived guanine DNA lesion in TGT and CGC sequence contexts: enhanced mobility in TGT explains conformational heterogeneity, flexible bending, and greater susceptibility to nucleotide excision repair.
P2860
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P2860
Relating repair susceptibility of carcinogen-damaged DNA with structural distortion and thermodynamic stability
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
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2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
name
Relating repair susceptibility ...... on and thermodynamic stability
@ast
Relating repair susceptibility ...... on and thermodynamic stability
@en
Relating repair susceptibility ...... on and thermodynamic stability
@nl
type
label
Relating repair susceptibility ...... on and thermodynamic stability
@ast
Relating repair susceptibility ...... on and thermodynamic stability
@en
Relating repair susceptibility ...... on and thermodynamic stability
@nl
prefLabel
Relating repair susceptibility ...... on and thermodynamic stability
@ast
Relating repair susceptibility ...... on and thermodynamic stability
@en
Relating repair susceptibility ...... on and thermodynamic stability
@nl
P2093
P2860
P356
P1476
Relating repair susceptibility ...... on and thermodynamic stability
@en
P2093
Dinshaw J Patel
Nicholas E Geacintov
Suse Broyde
P2860
P304
P356
10.1093/NAR/GKF427
P407
P50
P577
2002-08-01T00:00:00Z