A propofol binding site on mammalian GABAA receptors identified by photolabeling - Test2 - elhamkhani - TriplyDB

A propofol binding site on mammalian GABAA receptors identified by photolabeling

A propofol binding site on mammalian GABAA receptors identified by photolabeling

http://www.wikidata.org/entity/Q34372642

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Anesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptors Crystal structure of a human GABAA receptor Mutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anesthetics Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.Photoaffinity Labeling of Pentameric Ligand-Gated Ion Channels: A Proteomic Approach to Identify Allosteric Modulator Binding Sites.Curcumol allosterically modulates GABA(A) receptors in a manner distinct from benzodiazepines.Analogues of etomidate: modifications around etomidate's chiral carbon and the impact on in vitro and in vivo pharmacology Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol.Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties.Comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics.The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors Generation of recombinant antibodies to rat GABAA receptor subunits by affinity selection on synthetic peptides Dodecyl maltopyranoside enabled purification of active human GABA type A receptors for deep and direct proteomic sequencing Propofol inhibits SIRT2 deacetylase through a conformation-specific, allosteric site.Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function.Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors.Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry.Metabolomics profiling of pre-and post-anesthesia plasma samples of colorectal patients obtained via Ficoll separation.Propofol requirement for induction of unconsciousness is reduced in patients with Parkinson's disease: a case control study.A Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A Receptors Novel positive allosteric modulators of GABAA receptors with anesthetic activity.Inter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor.Role for the propofol hydroxyl in anesthetic protein target molecular recognition.A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of γ-Aminobutyric Acid, Type A (GABAA), Receptor Subunit Binding Selectivity in Synaptosomes.Neonatal Propofol and Etomidate Exposure Enhance Inhibitory Synaptic Transmission in Hippocampal Cornus Ammonis 1 Pyramidal Neurons.Mechanisms revealed through general anesthetic photolabeling.Noncompetitive Inhibition of 5-HT3 Receptors by Citral, Linalool, and Eucalyptol Revealed by Nonlinear Mixed-Effects Modeling.Development of Photoactivatable Allosteric Modulators for the Chemokine Receptor CXCR3.Orthosteric- versus allosteric-dependent activation of the GABAA receptor requires numerically distinct subunit level rearrangements.The actions of drug combinations on the GABAA receptor manifest as curvilinear isoboles of additivity.Differential Potency of 2,6-Dimethylcyclohexanol Isomers for Positive Modulation of GABAA Receptor Currents.Shedding Light on Anesthetic Mechanisms: Application of Photoaffinity Ligands.Mapping General Anesthetic Sites in Heteromeric γ-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes.Structural mechanisms of activation and desensitization in neurotransmitter-gated ion channels.Identification of a putative binding site critical for general anesthetic activation of TRPA1.Detergents: Friends not foes for high-performance membrane proteomics toward precision medicine.Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What?Identification of amino acids involved in histamine potentiation of GABA A receptors.Photoaffinity labeling the propofol binding site in GLIC.

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P2860

A propofol binding site on mammalian GABAA receptors identified by photolabeling

http://www.wikidata.org/entity/Q34372642

description

2013 nî lūn-bûn

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2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

A propofol binding site on mammalian GABAA receptors identified by photolabeling

@ast

A propofol binding site on mammalian GABAA receptors identified by photolabeling

@en

A propofol binding site on mammalian GABAA receptors identified by photolabeling

@nl

type

label

A propofol binding site on mammalian GABAA receptors identified by photolabeling

@ast

A propofol binding site on mammalian GABAA receptors identified by photolabeling

@en

A propofol binding site on mammalian GABAA receptors identified by photolabeling

@nl

prefLabel

A propofol binding site on mammalian GABAA receptors identified by photolabeling

@ast

A propofol binding site on mammalian GABAA receptors identified by photolabeling

@en

A propofol binding site on mammalian GABAA receptors identified by photolabeling

@nl

P1433

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Nature Chemical Biology

P1476

A propofol binding site on mammalian GABAA receptors identified by photolabeling

@en

P2093

Christopher J Edge

http://www.w3.org/2001/XMLSchema#string

Edward H Smith

http://www.w3.org/2001/XMLSchema#string

Erhard Hohenester

http://www.w3.org/2001/XMLSchema#string

Grace M S Yip

http://www.w3.org/2001/XMLSchema#string

Karoline Fuchs

http://www.w3.org/2001/XMLSchema#string

R Reid Townsend

http://www.w3.org/2001/XMLSchema#string

Robert Dickinson

http://www.w3.org/2001/XMLSchema#string

Zi-Wei Chen

http://www.w3.org/2001/XMLSchema#string

P2860

Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures

Mutational analysis of molecular requirements for the actions of general anaesthetics at the gamma-aminobutyric acidA receptor subtype, alpha1beta2gamma2

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

Principles of activation and permeation in an anion-selective Cys-loop receptor

A statistical model for identifying proteins by tandem mass spectrometry

Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics

Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain.

Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors.

A residue in loop 9 of the beta2-subunit stabilizes the closed state of the GABAA receptor.

A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors

P2888

P304

715-720

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scholarly article

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10.1038/NCHEMBIO.1340

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11

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P478

9

http://www.w3.org/2001/XMLSchema#string

P50

Nicholas Franks

Werner Sieghart

P577

2013-09-22T00:00:00Z

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P5875

256930066

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24056400

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3951778

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