Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice.
about
Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1The RUNX genes: gain or loss of function in cancerChromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatallyMurine models of acute leukemia: important tools in current pediatric leukemia research.Pathogenesis of ETV6/RUNX1-positive childhood acute lymphoblastic leukemia and mechanisms underlying its relapseSynergistic effect of Bcl2, Myc and Ccnd1 transforms mouse primary B cells into malignant cells.Role of the erythropoietin receptor in ETV6/RUNX1-positive acute lymphoblastic leukemia.TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia.Clonal origins of ETV6-RUNX1⁺ acute lymphoblastic leukemia: studies in monozygotic twins.Developmental origins and impact of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph+ acute lymphoblastic leukemiaTEL-AML1 regulation of survivin and apoptosis via miRNA-494 and miRNA-320aThe Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.Acute myeloid leukemia stem cells.Developmental impact of leukemic fusion genes on stem cell fate.Determination of ETV6-RUNX1 genomic breakpoint by next-generation sequencing.Mechanisms of transcription factor deregulation in lymphoid cell transformation.The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells.Unique long non-coding RNA expression signature in ETV6/RUNX1-driven B-cell precursor acute lymphoblastic leukemia.RUNX1 translocations and fusion genes in malignant hemopathies.Mechanisms of defective erythropoiesis and anemia in pediatric acute lymphoblastic leukemia (ALL).Revealing the role of TEL/AML1 for leukemic cell survival by RNAi-mediated silencing.RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.Mouse models for core binding factor leukemia.Mechanism of ETV6-RUNX1 Leukemia.The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods.Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice.RNAi-mediated silencing of TEL/AML1 reveals a heat-shock protein- and survivin-dependent mechanism for survival.Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemiaModelling how initiating and transforming oncogenes cooperate to produce a leukaemic cell stateCooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice.ETV6/RUNX1 induces reactive oxygen species and drives the accumulation of DNA damage in B cells.Initially disadvantaged, TEL-AML1 cells expand and initiate leukemia in response to irradiation and cooperating mutations.Modeling the process of childhood ETV6-RUNX1 B-cell leukemias.A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1.Molecular processes involved in B cell acute lymphoblastic leukaemia.TEL (ETV6)-AML1 (RUNX1) initiates self-renewing fetal pro-B cells in association with a transcriptional program shared with embryonic stem cells in mice.High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression.[Genetic basis of leukemia: Serious consequences of chromosomal translocations].TEL/AML1-positive patients lacking TEL exon 5 resemble canonical TEL/AML1 cases.
P2860
Q27307661-6C0E63E3-7801-4FA1-9099-24545F05D686Q28247901-69945EFA-B9EB-4DB8-9896-51498DE8EDDDQ28756307-7845425C-9D35-4A0C-B291-2569DE400414Q33606018-CC483CC5-ABEA-4423-8225-B9DDCAE578B4Q33798890-222E9C31-67BE-40FB-9318-FCC5B1B0CEACQ33909737-DD747BBA-7A41-4D70-B4D6-4E2A3EF01268Q34326017-3AF9C775-C40A-4777-B2B9-F03DAF88298FQ35108114-96065DDB-1D72-43D4-A0D9-224E0035F2DAQ35411913-AA1AC256-9F03-4CF3-80DC-82408454FD99Q35553341-59F0BD7E-C30F-48D3-B722-D71537CD52B9Q35691855-5EC2D0E8-6ABE-4CC9-BBD6-DA5C904310A0Q36128393-D0389360-9A15-4194-ACF2-61233DBD3C14Q36164458-9A1AD186-58A1-4C44-80E5-4368EAD14B1FQ36164466-E8C1FCF6-9432-4CDF-8957-2A652B63EB32Q36528412-8ACE8739-AA98-42D2-9384-F2E990735C51Q36970219-C5760F4D-B830-458F-A12F-EABF53851BB0Q37143354-0372532B-F436-403A-B2CF-C077FF412DA5Q37687468-E719A9E7-F109-4DEB-A113-F8CAFA02C530Q37822736-6193E233-58B6-48CB-B689-60F788257653Q38006380-574D20B2-EFE8-4594-9549-4DBBA7AD79CEQ38339066-078CF017-E1B6-4C33-B5CD-C6AE92FD0337Q38367298-F45CF48D-718A-4AEB-8A29-A3EEBF976E79Q38545496-40F3424A-2A82-44B6-A986-D7E4E67A11C4Q38744459-64445630-084E-4797-BB12-04F0D89F4EDBQ39079942-CFCAB915-B993-4E75-AD16-A0344F8120A2Q39746689-74774816-EB4B-4605-B0CA-998C6D0D3494Q40210058-BEBDFCD4-A33E-48A0-8B5C-EC2E6F163518Q41473465-026C5AD1-781C-4A0A-80DA-2E14364D9E16Q42426969-07BA7CE9-6524-47F0-BB18-FB3152440FB8Q42594064-6D43CAD1-A91C-4593-AC89-0FB955570282Q42821539-DEBA80E0-0860-45D8-B8F9-9910CDF56BB2Q43085894-7B28E16A-8592-4969-BC4D-305A76A66AE5Q47107870-825483D9-38D0-429B-B6E9-B2E16F6894B4Q47207770-6A023832-552B-4C69-8E24-10BF9A0720E1Q48218289-DEE750CA-DE32-4F7C-83FC-E06FB1D48CA1Q53135188-B029E07E-4C5A-4A1B-80D7-B7930CE54FCAQ53558606-2F719383-0FEC-4F0A-BB7B-D1D2A20F0660Q53742253-26106F57-8FF0-491C-AB6B-897FAFABCF95Q54397331-B53A90FB-8F86-4A73-B7C1-693AA018576C
P2860
Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice.
description
2004 nî lūn-bûn
@nan
2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Modeling first-hit functions of the t
@nl
Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice.
@ast
Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice.
@en
type
label
Modeling first-hit functions of the t
@nl
Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice.
@ast
Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice.
@en
prefLabel
Modeling first-hit functions of the t
@nl
Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice.
@ast
Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice.
@en
P2860
P356
P1476
Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice.
@en
P2093
Masao Seto
Shinobu Tsuzuki
P2860
P304
P356
10.1073/PNAS.0402063101
P407
P577
2004-05-20T00:00:00Z