Disruption of the mthfd1 gene reveals a monofunctional 10-formyltetrahydrofolate synthetase in mammalian mitochondria.
about
The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functionalA common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiencyALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenaseMitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryosMammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissuesA genetic signature of spina bifida risk from pathway-informed comprehensive gene-variant analysisPhylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymesMagnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase.Disruption of the folate pathway in zebrafish causes developmental defectsMthfd1 is a modifier of chemically induced intestinal carcinogenesis.Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis.Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview.Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in miceMthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major.The enzymes of the 10-formyl-tetrahydrofolate synthetic pathway are found exclusively in the cytosol of the trypanosomatid parasite Leishmania major.Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users.Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells.In silico experimentation with a model of hepatic mitochondrial folate metabolism.MTHFR c.1793G>A polymorphism is associated with congenital cardiac disease in a Chinese population.
P2860
Q24336719-D4CB94FF-4C11-4FC1-8486-46AB78700BF4Q24646784-208C2561-954B-4DCB-816A-90B0D07DA3E9Q28118977-9FA7ADC2-0249-4CF7-AF3A-357FA9A6B397Q28506233-7B290BDC-4A41-4EF0-A9FA-30D2D8A802D5Q28571107-EB758754-4D78-487C-85DC-F261582139D0Q28742080-560A9261-09DA-44BF-AA8F-631CC979BBE8Q28744169-41051D0B-277D-4018-9A86-C8EF8B814C98Q30668561-E685C9B1-6B55-4441-A0B7-9B821807B8A9Q34222885-608092E7-4B00-4CFE-9A14-A65AE122252DQ34617243-2E9B4460-782E-4C5C-B9AB-1E1D33D97317Q34985462-71A90C22-7588-40C1-88D0-0E089BFCD1BDQ35619839-8C3E4322-0AD5-4B3E-B4D6-B4E3243DDF72Q35826415-3C4168BE-3A0E-456B-B955-82D287C7BCCFQ37041614-41C9B65D-2408-4613-9945-50D999F79105Q37217438-37AFBA77-91B5-493E-9AE4-7CC7D9B82474Q37217459-7F979573-2496-4AEC-B36F-156BBE7F1F9FQ37673171-24192EF5-5C4D-47F1-8E27-6CBD78EDFF76Q38947506-36B80D62-2E1C-4D0D-9224-152AE649BFF8Q41763852-6A10CFDE-C0A6-4E1C-B56F-7FD951E1C0BCQ43107050-982D02EF-1EA6-4727-B453-0F0EA0BB6CBA
P2860
Disruption of the mthfd1 gene reveals a monofunctional 10-formyltetrahydrofolate synthetase in mammalian mitochondria.
description
2004 nî lūn-bûn
@nan
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Disruption of the mthfd1 gene ...... ase in mammalian mitochondria.
@ast
Disruption of the mthfd1 gene ...... ase in mammalian mitochondria.
@en
Disruption of the mthfd1 gene ...... ase in mammalian mitochondria.
@nl
type
label
Disruption of the mthfd1 gene ...... ase in mammalian mitochondria.
@ast
Disruption of the mthfd1 gene ...... ase in mammalian mitochondria.
@en
Disruption of the mthfd1 gene ...... ase in mammalian mitochondria.
@nl
prefLabel
Disruption of the mthfd1 gene ...... ase in mammalian mitochondria.
@ast
Disruption of the mthfd1 gene ...... ase in mammalian mitochondria.
@en
Disruption of the mthfd1 gene ...... ase in mammalian mitochondria.
@nl
P2093
P2860
P356
P1476
Disruption of the mthfd1 gene ...... ase in mammalian mitochondria.
@en
P2093
Harshila Patel
Karen E Christensen
Narciso R Mejia
Robert E MacKenzie
Uros Kuzmanov
P2860
P304
P356
10.1074/JBC.M409380200
P407
P577
2004-12-16T00:00:00Z