Role of drug metabolism in drug discovery and development. - Test2 - elhamkhani - TriplyDB

Role of drug metabolism in drug discovery and development.

Role of drug metabolism in drug discovery and development.

http://www.wikidata.org/entity/Q34386829

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Lead Optimization in Discovery Drug Metabolism and Pharmacokinetics/Case study: The Hepatitis C Virus (HCV) Protease Inhibitor SCH 503034 Pharmacokinetics, Tissue Distribution, and Anti-Lipogenic/Adipogenic Effects of Allyl-Isothiocyanate Metabolites Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR HSCCC-based strategy for preparative separation of in vivo metabolites after administration of an herbal medicine: Saussurea laniceps, a case study CYP3A4 overexpression enhances the cytotoxicity of the antitumor triazoloacridinone derivative C-1305 in CHO cells.Pharmacokinetics and its role in small molecule drug discovery research.The Simplest Flowchart Stating the Mechanisms for Organic Xenobiotics-induced Toxicity: Can it Possibly be Accepted as a "Central Dogma" for Toxic Mechanisms?Profiling the reactive metabolites of xenobiotics using metabolomic technologies The effect of therapeutic hypothermia on drug metabolism and response: cellular mechanisms to organ function In vitro tests for predicting drug-drug interactions: the need for validated procedures.Can formulation and drug delivery reduce attrition during drug discovery and development-review of feasibility, benefits and challenges.Differential effects of histone deacetylase inhibitors in tumor and normal cells-what is the toxicological relevance?Microbial metabolism studies of cyanthiwigin B and synergetic antibiotic effects Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells.Interspecies Variation of In Vitro Stability and Metabolic Diversity of YZG-331, a Promising Sedative-Hypnotic Compound.A Case-Based Approach to Integrating Opioid Pharmacokinetic and Pharmacodynamic Concepts in Cancer Pain Management.Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling Site of Metabolism Prediction Based on ab initio Derived Atom Representations.The Isoxazole Ring and Its N-Oxide: A Privileged Core Structure in Neuropsychiatric Therapeutics.Effects of Curcuma xanthorrhiza Extracts and Their Constituents on Phase II Drug-metabolizing Enzymes Activity.Metabolic Instability of Cyanothiazolidine-Based Prolyl Oligopeptidase Inhibitors: a Structural Assignment Challenge and Potential Medicinal Chemistry Implications.A simple model predicts UGT-mediated metabolism.Cytochrome P450 structure-function: insights from molecular dynamics simulations.A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.Uptake, biotransformation and elimination of selected pharmaceuticals in a freshwater invertebrate measured using liquid chromatography tandem mass spectrometry.The use of immobilized cytochrome P4502C9 in PMMA-based plug flow bioreactors for the production of drug metabolites Effects of meal composition and meal timing on the expression of genes involved in hepatic drug metabolism in rats.Identification of an Orally Efficacious GPR40/FFAR1 Receptor Agonist.Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950.In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes.Comparison of metabolic pathways of different α-N-heterocyclic thiosemicarbazones.Metabolism elucidation of BJ-B11 (a heat shock protein 90 inhibitor) by human liver microsomes: identification of main contributing enzymes.Characterization of in vivo metabolites in rat urine following an oral dose of masitinib by liquid chromatography tandem mass spectrometry.Enantioselective metabolism and toxic effects of metalaxyl on primary hepatocytes from rat.

P2860

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P2860

Role of drug metabolism in drug discovery and development.

http://www.wikidata.org/entity/Q34386829

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2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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Role of drug metabolism in drug discovery and development.

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Medicinal Research Reviews

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Role of drug metabolism in drug discovery and development.

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Kumar GN

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Surapaneni S

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P2860

Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment.

The human CYP3A subfamily: practical considerations.

In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase.

Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors.

Metabolic activation of carcinogens.

Relevance of induction of human drug-metabolizing enzymes: pharmacological and toxicological implications

The human hepatic cytochromes P450 involved in drug metabolism.

Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions.

Substrate interaction with cytochrome P-450.

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.

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397-411

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scholarly article

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10.1002/MED.1016

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5

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21

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2001-09-01T00:00:00Z

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11579440

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