Minor-groove-modulating adenosine replacements control protein binding and RNAi activity in siRNAs
about
Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviralNovel modifications in RNA8-Oxoguanosine switches modulate the activity of alkylated siRNAs by controlling steric effects in the major versus minor grooves.Nucleobase and ribose modifications control immunostimulation by a microRNA-122-mimetic RNA.Conjugation and Evaluation of Small Hydrophobic Molecules to Triazole-Linked siRNAs.Base modification strategies to modulate immune stimulation by an siRNA.7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groovePromiscuous 8-alkoxyadenosines in the guide strand of an siRNA: modulation of silencing efficacy and off-pathway protein binding.Short interfering RNA guide strand modifiers from computational screening.Chemical modification of siRNA bases to probe and enhance RNA interference.Chemical architecture and applications of nucleic acid derivatives containing 1,2,3-triazole functionalities synthesized via click chemistry.Synthesis of N2-alkyl-8-oxo-7,8-dihydro-2'-deoxyguanosine derivatives and effects of these modifications on RNA duplex stability.Transcription of 4'-thioDNA templates to natural RNA in vitro and in mammalian cells.Groove modification of siRNA duplexes to elucidate siRNA-protein interactions using 7-bromo-7-deazaadenosine and 3-bromo-3-deazaadenosine as chemical probes.
P2860
Q28302608-58EF4EB7-5113-4F20-A4D8-760F1267DFF5Q28732267-D72ECB29-9838-4EDD-A93A-EA8E3354CCC0Q34906848-733E1537-A8EF-423F-B1C9-26BCF5C6001BQ35048102-9E787180-2F7A-49B6-9CB5-465290B62AD1Q35086755-A6246B55-3774-4182-ACB8-9F01BD77B7FFQ35112225-7EB9F5B0-76AF-41ED-89CD-F5EFDB57140FQ36160120-A31C5A20-8A76-4D7E-B9CE-AE448C23A563Q36379706-FB365D36-BB2F-4A15-964A-CB09A41DB007Q37449572-2B58E152-86D5-4103-B790-CD49BB0A386DQ37915505-188505A8-DF60-4510-A55F-A13326383BD2Q38056000-A0B15D85-EB60-49B0-9184-7CAD383FC8D1Q42577743-6FA7EF33-E8BA-47D6-8267-57DC4AC77371Q42828635-D07E24CA-D2EA-414E-996C-2F4842AC0AFEQ51420935-ADB5E828-835B-48D6-B57C-0D17D01D6A3F
P2860
Minor-groove-modulating adenosine replacements control protein binding and RNAi activity in siRNAs
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Minor-groove-modulating adenos ...... ng and RNAi activity in siRNAs
@ast
Minor-groove-modulating adenos ...... ng and RNAi activity in siRNAs
@en
Minor-groove-modulating adenos ...... ng and RNAi activity in siRNAs
@nl
type
label
Minor-groove-modulating adenos ...... ng and RNAi activity in siRNAs
@ast
Minor-groove-modulating adenos ...... ng and RNAi activity in siRNAs
@en
Minor-groove-modulating adenos ...... ng and RNAi activity in siRNAs
@nl
prefLabel
Minor-groove-modulating adenos ...... ng and RNAi activity in siRNAs
@ast
Minor-groove-modulating adenos ...... ng and RNAi activity in siRNAs
@en
Minor-groove-modulating adenos ...... ng and RNAi activity in siRNAs
@nl
P2860
P356
P1433
P1476
Minor-groove-modulating adenos ...... ng and RNAi activity in siRNAs
@en
P2093
Erik Fostvedt
Peter A Beal
P2860
P304
P356
10.1021/CB100245U
P577
2010-10-07T00:00:00Z