Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius. - Test2 - elhamkhani - TriplyDB

Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius.

Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius.

http://www.wikidata.org/entity/Q34454224

about

Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.The Streptomyces peucetius dpsC gene determines the choice of starter unit in biosynthesis of the daunorubicin polyketide.Accessing Nature's diversity through metabolic engineering and synthetic biology Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus Evolution of High Cellulolytic Activity in Symbiotic Streptomyces through Selection of Expanded Gene Content and Coordinated Gene Expression Natural-product sugar biosynthesis and enzymatic glycodiversification.Combinatorial biosynthesis--potential and problems.Pseudomonas syringae phytotoxins: mode of action, regulation, and biosynthesis by peptide and polyketide synthetases Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus Metabolic engineering for the production of natural products.Pharmacognosy in the new millennium: leadfinding and biotechnology.Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027.Recombinant E. coli prototype strains for in vivo glycorandomization.Mechanistic studies of the biosynthesis of 2-thiosugar: evidence for the formation of an enzyme-bound 2-ketohexose intermediate in BexX-catalyzed reaction Engineered biosynthesis of aklanonic acid analogues Characterization of FdmV as an amide synthetase for fredericamycin A biosynthesis in Streptomyces griseus ATCC 43944.BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin.Streptomyces genetics: a genomic perspective.Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates.Chemobiosynthesis of new antimalarial macrolides.Identification and utility of FdmR1 as a Streptomyces antibiotic regulatory protein activator for fredericamycin production in Streptomyces griseus ATCC 49344 and heterologous hosts.Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products.Decoding and engineering tetracycline biosynthesis.Hyper-inducible expression system for streptomycetes Hutchinson's legacy: keeping on polyketide biosynthesis.Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.Natural products for cancer chemotherapy.Metabolic engineering is key to a sustainable chemical industry.Perspectives in metabolic engineering: understanding cellular regulation towards the control of metabolic routes.Regulation of daunorubicin biosynthesis in Streptomyces peucetius - feed forward and feedback transcriptional control.Elucidation of the glycosylation steps during biosynthesis of antitumor macrolides PM100117 and PM100118 and engineering for novel derivatives.Anthraquinones As Pharmacological Tools and Drugs.New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster.Aclacinomycin 10-hydroxylase is a novel substrate-assisted hydroxylase requiring S-adenosyl-L-methionine as cofactor.An enzyme module system for the synthesis of dTDP-activated deoxysugars from dTMP and sucrose.Special issue of The Journal of Antibiotics dedicated to the late Professor C Richard Hutchinson.A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea.Bioconversion of deoxysugar moieties to the biosynthetic intermediates of daunorubicin in an engineered strain of Streptomyces coeruleobidus.

P2860

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P2860

Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius.

http://www.wikidata.org/entity/Q34454224

description

1998 nî lūn-bûn

@nan

1998 թուականի Յունուարին հրատարակուած գիտական յօդուած

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1998 թվականի հունվարին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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name

Production of the antitumor dr ...... ain of Streptomyces peucetius.

@ast

Production of the antitumor dr ...... ain of Streptomyces peucetius.

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Production of the antitumor drug epirubicin

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type

label

Production of the antitumor dr ...... ain of Streptomyces peucetius.

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Production of the antitumor dr ...... ain of Streptomyces peucetius.

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Production of the antitumor drug epirubicin

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prefLabel

Production of the antitumor dr ...... ain of Streptomyces peucetius.

@ast

Production of the antitumor dr ...... ain of Streptomyces peucetius.

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Production of the antitumor drug epirubicin

@nl

P1433

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P2860

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P1433

Nature Biotechnology

P1476

Production of the antitumor dr ...... ain of Streptomyces peucetius.

@en

P2093

Colombo AL

http://www.w3.org/2001/XMLSchema#string

Filippini S

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Gewain KM

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Hutchinson CR

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Inventi-Solari A

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Kennedy J

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MacNeil DJ

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Madduri K

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Occi JL

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Rivola G

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P2860

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors

Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis.

Production of a hybrid macrolide antibiotic in Streptomyces ambofaciens and Streptomyces lividans by introduction of a cloned carbomycin biosynthetic gene from Streptomyces thermotolerans.

Generation of polyketide libraries via combinatorial biosynthesis.

Effectiveness of anthracycline against experimental prion disease in Syrian hamsters.

P2888

P304

69-74

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scholarly article

P356

10.1038/NBT0198-69

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1

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P478

16

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P577

1998-01-01T00:00:00Z

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13782309

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P6179

1033001640

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P698

9447597

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