Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis. - Test2 - elhamkhani - TriplyDB

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

http://www.wikidata.org/entity/Q34455322

about

Signaling in Fibrosis: TGF-β, WNT, and YAP/TAZ Converge TGF-β/Smad signaling in renal fibrosis Smads as therapeutic targets for chronic kidney disease TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation Role of the TGF-β/BMP-7/Smad pathways in renal diseases TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis L-Endoglin overexpression increases renal fibrosis after unilateral ureteral obstruction.Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-β/Smad3-NF.κB-dependent mechanisms in mice.Deficiency of Smad7 enhances cardiac remodeling induced by angiotensin II infusion in a mouse model of hypertension Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney.MicroRNAs in renal fibrosis.Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling.TGF-β/Smad3 signaling promotes renal fibrosis by inhibiting miR-29 Genetic deficiency of Smad3 protects against murine ischemic acute kidney injury.TGFβ-induced deptor suppression recruits mTORC1 and not mTORC2 to enhance collagen I (α2) gene expression.Retinoic acid promotes myogenesis in myoblasts by antagonizing transforming growth factor-beta signaling via C/EBPβ Sorafenib ameliorates renal fibrosis through inhibition of TGF-β-induced epithelial-mesenchymal transition.Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor β (TGF-β) pathway.Two sides of the story? Smad4 loss in pancreatic cancer versus head-and-neck cancer Differential expression and therapeutic efficacy of microRNA-346 in diabetic nephropathy mice Smad7 protects against chronic aristolochic acid nephropathy in mice.GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-β-Induced Smad3 Phosphorylation Renal interstitial fibrosis: mechanisms and evaluation.miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice.Activation of Wnt11 by transforming growth factor-β drives mesenchymal gene expression through non-canonical Wnt protein signaling in renal epithelial cells Sorting nexin 9 differentiates ligand-activated Smad3 from Smad2 for nuclear import and transforming growth factor β signaling.Epithelial-mesenchymal transition and fibrosis are mutually exclusive reponses in shear-activated proximal tubular epithelial cells.P311 promotes renal fibrosis via TGFβ1/Smad signaling.Identification of Genes Associated with Smad3-dependent Renal Injury by RNA-seq-based Transcriptome Analysis.Treatment of renal fibrosis by rebalancing TGF-β/Smad signaling with the combination of asiatic acid and naringenin.Diabetic nephropathy: the role of inflammation in fibroblast activation and kidney fibrosis.Transforming growth factor β integrates Smad 3 to mechanistic target of rapamycin complexes to arrest deptor abundance for glomerular mesangial cell hypertrophy.TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis.Long Noncoding RNA Arid2-IR Is a Novel Therapeutic Target for Renal Inflammation TGF-β signaling in the kidney: profibrotic and protective effects Shengmai San Ameliorates Myocardial Dysfunction and Fibrosis in Diabetic db/db Mice.TGF-β/Smad3 signalling regulates the transition of bone marrow-derived macrophages into myofibroblasts during tissue fibrosis Targeting c-fms kinase attenuates chronic aristolochic acid nephropathy in mice Renoprotective Effect of Gemigliptin, a Dipeptidyl Peptidase-4 Inhibitor, in Streptozotocin-Induced Type 1 Diabetic Mice.

P2860

Q26782820-E2F9899D-A6B0-4B8F-8615-A3AD7FF49CEC Q26851198-B7296286-8E8A-4390-B7AB-BE7FC8D0DEA4 Q26865998-D8228B93-E7A0-4613-9D64-836720A4F2EE Q28067425-2B22E2B2-A025-4A7E-B4B2-84E609FD8713 Q28278757-58213604-7B41-4A10-8875-BC7B8589B989 Q28975741-5C882AF0-4BB8-45BE-B4DA-5B4474D97AD2 Q30836201-38F0501D-DD86-4A8C-B8EC-F93AC2CF8846 Q34338572-6953BA7A-1223-4837-8BAA-530BEB8514CA Q34542559-F9D9EE25-7C4E-4D1A-9F73-D756D38BCD4C Q34875675-A1AC5322-09D0-4F0A-9E37-FB7BE383DEEF Q35082779-817AAA21-D3EF-48A3-B2F2-08BD07D7D7C7 Q35104478-63518AC4-9A07-4CBD-8D85-C2B004C2AE8D Q35110925-E771002E-1E76-40B2-8832-2582C9893C8A Q35142712-61D8CB12-23AB-4DCC-A834-5022C987FCF9 Q35159549-EFB46909-D402-4B1D-9C7C-7252F17BC2AE Q35354812-1E7BA1E4-401D-45A4-8E23-4111B0A07C1B Q35426456-DD9D696C-E090-4EBF-BA4D-9DE13439E121 Q35560583-47FC884E-18C7-4569-A6F4-6BA6C5EAACFE Q35561112-20A475EC-1C88-4FC5-9DC8-1BDDEE796AB6 Q35774267-E72A2B59-5151-4366-AAE0-A45CA4EE6915 Q35802995-15FB3673-37BD-473F-9AA1-3CCFC35679CC Q35828473-9C3B59B8-B189-4155-9AB4-4FE304B71DE2 Q35903089-E639A640-64D3-407C-81D8-E9A06E9AEDBC Q35967489-47D2FA87-EA64-40BE-B4C7-254241D9E978 Q36014083-351A47B7-F58D-4599-9938-E876721C843D Q36033247-5CBF4F88-F1D4-4B3F-B055-7C23830A4434 Q36224600-973AAE21-0538-4372-841E-9E940BF2FA93 Q36252368-FD806152-127C-4DF2-AA8C-58BF03D45B7E Q36330422-635C2163-8918-41AE-BBE5-40F9D129D54E Q36356793-671C1419-D7F8-4D81-971A-3AEDBE6FF029 Q36545653-2AABC52D-F8A0-4A0A-A39B-1EF903BC6CD3 Q36589609-21D801A2-AC6C-408B-8B17-D3ABFD8E98C3 Q36685205-D5CB395B-6A4B-42B3-B3E2-A78230DA7BF1 Q36737131-38673009-2E74-4EF2-B32C-9B2866716DD4 Q36756684-E2F1F60B-6775-4B65-90A6-C9DA8027532C Q36775661-69B16AAE-9CDA-4787-9355-F8A545391A4B Q36870324-B72393CB-CFFE-4F32-912F-C9EF4F110AE6 Q36962418-9B0F17DD-CF9B-4215-A19B-387428B6CBAD Q36998106-6FEC60F9-A77A-44A1-8E58-B1A6D125ECF5 Q37056839-09B8F4CA-C2F2-4E0E-8463-9D75D45BE185

P2860

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

http://www.wikidata.org/entity/Q34455322

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

@ast

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

@en

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

@nl

type

label

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

@ast

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

@en

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

@nl

prefLabel

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

@ast

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

@en

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

@nl

P1433

Q34455322-086CECAA-E0E6-4640-AA06-F531672501E3

P1476

Q34455322-8C276AEB-AE51-431C-A70C-4456C080031E

P2093

Q34455322-2A08C440-12CA-409E-B6A0-345C54D13902

Q34455322-4CC33B40-75A0-4B26-AFEC-1F0D0994331A

Q34455322-5D7FDEBF-7F35-48D7-837A-428180B5ABDD

Q34455322-6CBD8277-3EA4-47C3-B089-F4DE0CF41D9D

Q34455322-B2DA4A11-53DF-40EF-97FE-A47751F719A9

Q34455322-E5B54815-AAC0-492D-B2FC-C599A39B3A7D

Q34455322-FC160DA0-898F-4AE5-B99F-18948A7164AA

P2860

Q34455322-0C4A01D1-545B-4B3F-83EC-BB779EBABF63

Q34455322-0CDD99B6-49A3-4D4F-8352-2D7F1AE13501

Q34455322-291744F2-6ADC-452E-BDD6-FA796314D020

Q34455322-3E96096A-9F6F-4B5B-AC25-52E7BE0A11A3

Q34455322-3EA88477-906D-47E2-8C16-DF66DB5AB8AC

Q34455322-423C75FE-AD72-4675-A19C-8C794779793B

Q34455322-453B8652-DD29-44E1-8ABD-081CA8DAE6E2

Q34455322-461C665A-05F8-429F-898B-B869B2E8B15A

Q34455322-494310AA-AB39-4AFC-8EEB-3B87C11F7E85

Q34455322-4CD0C135-6184-4E37-9DD0-5639414DDA64

P304

Q34455322-6BCB01B3-851F-46F8-87D6-49B8FB46A5AB

P31

Q34455322-F9B37222-526C-4A14-8D56-C8DE7FF30946

P356

Q34455322-DF71D07D-6F6B-44CB-91F9-37855A62FFFA

P433

Q34455322-16367A05-D47D-4FFB-A462-56257C11CD24

P478

Q34455322-310101D4-6874-4E34-8BB3-14D968EADF84

P50

Q34455322-489C7DF3-1C30-4162-9336-82ADD9F1CE59

Q34455322-D8D080AD-45B4-4A4C-ADFA-5EE5DDBD1362

P577

Q34455322-951B1562-52F0-4C1D-899D-846155510B7A

P698

Q34455322-7032FEE7-6893-41F9-99DF-0E9C21EFB43C

P932

Q34455322-4406990C-07A0-48BA-AA30-0D5636545B20

P356

P1433

Journal of the American Society of Nephrology

P1476

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis

@en

P2093

Arthur C K Chung

http://www.w3.org/2001/XMLSchema#string

Erwin P Bottinger

http://www.w3.org/2001/XMLSchema#string

Wei Qin

http://www.w3.org/2001/XMLSchema#string

Wenjun Ju

http://www.w3.org/2001/XMLSchema#string

Xiao Ming Meng

http://www.w3.org/2001/XMLSchema#string

Xiao Ru Huang

http://www.w3.org/2001/XMLSchema#string

Xinli Shao

http://www.w3.org/2001/XMLSchema#string

P2860

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and -independent Smad pathways: the role of Smad3

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene.

Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling.

Essential role of Smad3 in angiotensin II-induced vascular fibrosis

TGF-beta signaling in renal disease.

Smad3: a key player in pathogenetic mechanisms dependent on TGF-beta.

Smad3 as a mediator of the fibrotic response.

P304

1477-1487

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1681/ASN.2009121244

http://www.w3.org/2001/XMLSchema#string

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

21

http://www.w3.org/2001/XMLSchema#string

P50

P577

2010-07-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

20595680

http://www.w3.org/2001/XMLSchema#string

P932

3013519

http://www.w3.org/2001/XMLSchema#string