Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.
about
Cancer pharmacogenomics, challenges in implementation, and patient-focused perspectivesPharmacogenomics in the clinicUse of Thiopurines in Inflammatory Bowel Disease: A Consensus Statement by the Korean Association for the Study of Intestinal Diseases (KASID)Pharmacogenomics in Pediatric Oncology: Review of Gene-Drug Associations for Clinical UseHow I treat acute lymphoblastic leukemia in older adolescents and young adultsChildhood Acute Lymphoblastic Leukemia: Progress Through CollaborationCrystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicityThe Promise of Pharmacogenomics in Reducing Toxicity During Acute Lymphoblastic Leukemia Maintenance Treatment.Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia.Genetic factors affecting drug disposition in Asian cancer patients.Impact of NUDT15 polymorphisms on thiopurines-induced myelotoxicity and thiopurines tolerance dose.Inherited genetic variation in childhood acute lymphoblastic leukemia.Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia.Meta-analysis of the impact of thioprine S-methyltransferase polymorphisms on the tolerable 6-mercaptopurine dose considering initial dose and ethnic difference.Review article: recent advances in pharmacogenetics and pharmacokinetics for safe and effective thiopurine therapy in inflammatory bowel disease.Therapies on the horizon for childhood acute lymphoblastic leukemia.Personalizing chemotherapy dosing using pharmacological methods.The druggability of intracellular nucleotide-degrading enzymes.Toward Optimum Benefit-Risk and Reduced Access Lag For Cancer Drugs in Asia: A Global Development Framework Guided by Clinical Pharmacology Principles.Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease: A Multicenter Analysis.Interaction between NUDT15 and ABCC4 variants enhances intolerability of 6-mercaptopurine in Japanese patients with childhood acute lymphoblastic leukemia.Pharmacogenetic Predictors of Treatment-Related Toxicity Among Children With Acute Lymphoblastic Leukemia.Genome-Wide Association Studies of Chemotherapeutic Toxicities: Genomics of Inequality.Association of NUDT15 c.415C>T allele and thiopurine-induced leukocytopenia in Asians: a systematic review and meta-analysis.Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods.Maintenance therapy of childhood acute lymphoblastic leukemia revisited-Should drug doses be adjusted by white blood cell, neutrophil, or lymphocyte counts?Genotyping NUDT15 can predict the dose reduction of 6-MP for children with acute lymphoblastic leukemia especially at a preschool age.Infection-related mortality in Hispanic and non-Hispanic children with cancer.Comparison of Direct Sequencing, Real-Time PCR-High Resolution Melt (PCR-HRM) and PCR-Restriction Fragment Length Polymorphism (PCR-RFLP) Analysis for Genotyping of Common Thiopurine Intolerant Variant Alleles NUDT15 c.415C>T and TPMT c.719A>G (TPMTNUDT15, FTO, and RUNX1 genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases.NUDT15 c.415C>T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia.Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait.Novel Tetra-Primer ARMS-PCR Assays for Thiopurine Intolerance Susceptibility Mutations NUDT15 c.415C>T and TPMT c.719A>G (TPMT*3C) in East Asians.Antituberculosis Drug-Induced Adverse Events in the Liver, Kidneys, and Blood: Clinical Profiles and Pharmacogenetic Predictors.APEX1 Polymorphism and Mercaptopurine-Related Early Onset Neutropenia in Pediatric Acute Lymphoblastic Leukemia.Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity.NUDT15 polymorphism and severe azathioprine-induced myelosuppression in a Chinese man with pemphigus vulgaris.Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines.NUDT15 Variants Cause Hematopoietic Toxicity with Low 6-TGN Levels in Children with Acute Lymphoblastic Leukemia.
P2860
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P2860
Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.
description
2015 nî lūn-bûn
@nan
2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Inherited NUDT15 variant is a ...... acute lymphoblastic leukemia.
@ast
Inherited NUDT15 variant is a ...... acute lymphoblastic leukemia.
@en
Inherited NUDT15 variant is a ...... acute lymphoblastic leukemia.
@nl
type
label
Inherited NUDT15 variant is a ...... acute lymphoblastic leukemia.
@ast
Inherited NUDT15 variant is a ...... acute lymphoblastic leukemia.
@en
Inherited NUDT15 variant is a ...... acute lymphoblastic leukemia.
@nl
prefLabel
Inherited NUDT15 variant is a ...... acute lymphoblastic leukemia.
@ast
Inherited NUDT15 variant is a ...... acute lymphoblastic leukemia.
@en
Inherited NUDT15 variant is a ...... acute lymphoblastic leukemia.
@nl
P2093
P2860
P356
P1476
Inherited NUDT15 variant is a ...... acute lymphoblastic leukemia.
@en
P2093
Cheng Cheng
Chengcheng Liu
Deqing Pei
F Lennie Wong
Jun J Yang
Kristine R Crews
Lindsey Hageman
Mary V Relling
Nancy Kornegay
Smita Bhatia
P2860
P304
P356
10.1200/JCO.2014.59.4671
P407
P577
2015-01-26T00:00:00Z