Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen. - Test2 - elhamkhani - TriplyDB

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.

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Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway Interplay between Fanconi anemia and homologous recombination pathways in genome integrity Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3 Aldehyde dehydrogenase 2 in aplastic anemia, Fanconi anemia and hematopoietic stem cells S-Nitrosation of Conserved Cysteines Modulates Activity and Stability of S-Nitrosoglutathione Reductase (GSNOR)Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment 20S immunoproteasomes remove formaldehyde-damaged cytoplasmic proteins suppressing caspase-independent cell death.A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability.Development of a General Aza-Cope Reaction Trigger Applied to Fluorescence Imaging of Formaldehyde in Living Cells.Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction.Measurement of Endogenous versus Exogenous Formaldehyde-Induced DNA-Protein Crosslinks in Animal Tissues by Stable Isotope Labeling and Ultrasensitive Mass Spectrometry.When Genome Maintenance Goes Badly Awry.BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2(-/-) Hematopoietic Stem and Progenitor Cells.Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism What is the DNA repair defect underlying Fanconi anemia?Formaldehyde Is a Potent Proteotoxic Stressor Causing Rapid Heat Shock Transcription Factor 1 Activation and Lys48-Linked Polyubiquitination of Proteins.FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5'-DNA end.Fanconi Anemia: A DNA repair disorder characterized by accelerated decline of the hematopoietic stem cell compartment and other features of aging.A role for the base excision repair enzyme NEIL3 in replication-dependent repair of interstrand DNA cross-links derived from psoralen and abasic sites.The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy.Fluorescent probes for imaging formaldehyde in biological systems.Recent insights into the molecular basis of Fanconi anemia: genes, modifiers, and drivers.Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells.Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase.A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells Formaldehyde induces toxicity in mouse bone marrow and hematopoietic stem/progenitor cells and enhances benzene-induced adverse effects.Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2.Loss of the homologous recombination gene rad51 leads to Fanconi anemia-like symptoms in zebrafish.DNA Damage as a Driver for Growth Delay: Chromosome Instability Syndromes with Intrauterine Growth Retardation.RecQ and Fe-S helicases have unique roles in DNA metabolism dictated by their unwinding directionality, substrate specificity, and protein interactions.Neurotoxicity effect of formaldehyde on occupational exposure and influence of individual susceptibility to some metabolism parameters.N6-Formyllysine as a Biomarker of Formaldehyde Exposure: Formation and Loss of N6-Formyllysine in Nasal Epithelium in Long-Term, Low-Dose Inhalation Studies in Rats.Origin of low-molecular mass aldehydes as disinfection by-products in beverages.Recent advances in understanding hematopoiesis in Fanconi Anemia.Community interest and feasibility of using a novel smartphone-based formaldehyde exposure detection technology.Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice.Fanconi Anemia Signaling and Cancer.The phenotype and clinical course of Japanese Fanconi Anaemia infants is influenced by patient, but not maternal ALDH2 genotype.

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Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.

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2015 nî lūn-bûn

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2015 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2015 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.

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Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.

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Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.

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Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.

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J.MOLCEL.2015.08.020

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Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen

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Gayathri Chandrasekaran

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Guillermo Burgos-Barragan

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Instability and decay of the primary structure of DNA

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Nitric oxide synthase: non-canonical expression patterns

Metabolic methanol: molecular pathways and physiological roles

A DNA-dependent protease involved in DNA-protein crosslink repair.

Kinetic mechanism of human glutathione-dependent formaldehyde dehydrogenase

Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice

Rate of depurination of native deoxyribonucleic acid

Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock

Expanding chemical biology of 2-oxoglutarate oxygenases

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177-188

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