Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists. - Test2 - elhamkhani - TriplyDB

Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists.

Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists.

http://www.wikidata.org/entity/Q34535609

about

P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia Molecular and functional properties of P2X receptors--recent progress and persisting challenges Calcium influx pathways in breast cancer: opportunities for pharmacological intervention Ligation of CD40 in Human Müller Cells Induces P2X7 Receptor-Dependent Death of Retinal Endothelial Cells.A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory pain Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption.Synthesis and biochemical evaluation of triazole/tetrazole-containing sulfonamides against thrombin and related serine proteases.The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives P2X7 receptors mediate deleterious renal epithelial-fibroblast cross talk Activation and regulation of purinergic P2X receptor channels P2X7 receptor inhibition protects against ischemic acute kidney injury in mice.Calcium-dependent block of P2X7 receptor channel function is allosteric.The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice.Saffron reduces ATP-induced retinal cytotoxicity by targeting P2X7 receptors.Effects of toxic cellular stresses and divalent cations on the human P2X7 cell death receptor.Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation Selective P2X(7) receptor antagonists for chronic inflammation and pain Natural Products as a Source for New Anti-Inflammatory and Analgesic Compounds through the Inhibition of Purinergic P2X Receptors.Subfailure Overstretch Injury Leads to Reversible Functional Impairment and Purinergic P2X7 Receptor Activation in Intact Vascular Tissue P2X7 purinoceptors contribute to the death of Schwann cells transplanted into the spinal cord.Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.Physiological and pathological functions of P2X7 receptor in the spinal cord.Synthesis and structure-activity relationship studies of tyrosine-based antagonists at the human P2X7 receptor Recent patents on novel P2X(7) receptor antagonists and their potential for reducing central nervous system inflammation.Ion channel blockers for the treatment of neuropathic pain.Current and emerging "at-site" pain medications: a review P2X receptor antagonists for pain management: examination of binding and physicochemical properties.P2X and P2Y nucleotide receptors as targets in cardiovascular disease.A review of syntheses of 1,5-disubstituted tetrazole derivatives.Dissecting fibrosis: therapeutic insights from the small-molecule toolbox.Acupuncture-Induced Analgesia: A Neurobiological Basis in Purinergic Signaling.K(+) regulates Ca(2+) to drive inflammasome signaling: dynamic visualization of ion flux in live cells.The microglial ATP-gated ion channel P2X7 as a CNS drug target.R270C polymorphism leads to loss of function of the canine P2X7 receptor.CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation.Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects High throughput functional assays for P2X receptors.Novel P2X7 receptor antagonists ease the pain.P2X₇-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells.

P2860

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P2860

Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists.

http://www.wikidata.org/entity/Q34535609

description

2006 nî lūn-bûn

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2006 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2006 թվականի հունիսին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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Structure-activity relationshi ...... nyltetrazole P2X7 antagonists.

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Structure-activity relationshi ...... nyltetrazole P2X7 antagonists.

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Structure-activity relationshi ...... nyltetrazole P2X7 antagonists.

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Structure-activity relationshi ...... nyltetrazole P2X7 antagonists.

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Structure-activity relationshi ...... nyltetrazole P2X7 antagonists.

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Structure-activity relationshi ...... nyltetrazole P2X7 antagonists.

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Structure-activity relationshi ...... nyltetrazole P2X7 antagonists.

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Structure-activity relationshi ...... nyltetrazole P2X7 antagonists.

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Arturo Perez-Medrano

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Connie R Faltynek

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Derek W Nelson

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Diana L Donnelly-Roberts

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Eric A Voight

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George Grayson

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Marian T Namovic

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Michael E Kort

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Michael F Jarvis

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Prisca Honore

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10.1021/JM051202E

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12

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16759108

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