Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions. - Test2 - elhamkhani - TriplyDB

Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions.

Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions.

http://www.wikidata.org/entity/Q34550253

about

Controlled crystal dehydration triggers a space-group switch and shapes the tertiary structure of cytomegalovirus immediate-early 1 (IE1) protein Emerging Role of PML Nuclear Bodies in Innate Immune Signaling Positive role of promyelocytic leukemia protein in type I interferon response and its regulation by human cytomegalovirus.Assembly of Epstein-Barr Virus Capsid in Promyelocytic Leukemia Nuclear Bodies.Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response PML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence.Characterization of Recombinant Human Cytomegaloviruses Encoding IE1 Mutants L174P and 1-382 Reveals that Viral Targeting of PML Bodies Perturbs both Intrinsic and Innate Immune Responses Promyelocytic Leukemia Protein (PML) Controls Listeria monocytogenes Infection.The essential role of guinea pig cytomegalovirus (GPCMV) IE1 and IE2 homologs in viral replication and IE1-mediated ND10 targeting.The Human Cytomegalovirus IE1 Protein Antagonizes PML Nuclear Body-Mediated Intrinsic Immunity via the Inhibition of PML De Novo SUMOylation Analysis of the functional interchange between the IE1 and pp71 proteins of human cytomegalovirus and ICP0 of herpes simplex virus 1.Complete Genome Sequence of a Human Cytomegalovirus Strain AD169 Bacterial Artificial Chromosome Clone.Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase.The ND10 Component Promyelocytic Leukemia Protein Acts as an E3 Ligase for SUMOylation of the Major Immediate Early Protein IE1 of Human Cytomegalovirus.Investigation of the dynamics of the viral immediate-early protein 1 in different conformations and oligomerization states.Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs.The chromatin remodeling factor SPOC1 acts as a cellular restriction factor against human cytomegalovirus by repressing the major immediate-early promoter.Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.

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P2860

Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions.

http://www.wikidata.org/entity/Q34550253

description

2014 nî lūn-bûn

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2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2014年の論文

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2014年論文

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2014年論文

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Crystal structure of cytomegal ...... via coiled-coil interactions.

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Crystal structure of cytomegal ...... via coiled-coil interactions.

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Crystal structure of cytomegal ...... via coiled-coil interactions.

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Crystal structure of cytomegal ...... via coiled-coil interactions.

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Crystal structure of cytomegal ...... via coiled-coil interactions.

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Crystal structure of cytomegal ...... via coiled-coil interactions.

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Eva-Maria Schilling

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Joachim D Stump

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Madhumati Sevvana

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Myriam Scherer

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Nina Reuter

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Regina Müller

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Stefan Klingl

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Victoria Otto

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P2860

Differential regulation of sentrinized proteins by a novel sentrin-specific protease

Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infections

Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I

Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption

Proteasome-independent disruption of PML oncogenic domains (PODs), but not covalent modification by SUMO-1, is required for human cytomegalovirus immediate-early protein IE1 to inhibit PML-mediated transcriptional repression.

Inactivating a cellular intrinsic immune defense mediated by Daxx is the mechanism through which the human cytomegalovirus pp71 protein stimulates viral immediate-early gene expression

Structure of proteins: packing of alpha-helices and pleated sheets

Ability of the human cytomegalovirus IE1 protein to modulate sumoylation of PML correlates with its functional activities in transcriptional regulation and infectivity in cultured fibroblast cells

Using circular dichroism spectra to estimate protein secondary structure

PHENIX: a comprehensive Python-based system for macromolecular structure solution

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11

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10

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Heinrich Sticht

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Thomas Stamminger

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2014-11-20T00:00:00Z

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Cytomegalovirus

protein structure

crystal structure

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