Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia. - Test2 - elhamkhani - TriplyDB

Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.

Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.

http://www.wikidata.org/entity/Q34590391

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Positive and Negative Regulatory Mechanisms for Fine-Tuning Cellularity and Functions of Medullary Thymic Epithelial Cells Induction of central tolerance by the factor Aire: molecular and epigenetic regulation The Contribution of Chemokines and Migration to the Induction of Central Tolerance in the Thymus The Thymic Orchestration Involving Aire, miRNAs, and Cell-Cell Interactions during the Induction of Central Tolerance Exosomes in the Thymus: Antigen Transfer and Vesicles Thymic Crosstalk Coordinates Medulla Organization and T-Cell Tolerance Induction Promiscuous Gene Expression in the Thymus: A Matter of Epigenetics, miRNA, and More?CCR4 promotes medullary entry and thymocyte-dendritic cell interactions required for central tolerance.CGAT: a model for immersive personalized training in computational genomics.Novel Findings into AIRE Genetics and Functioning: Clinical Implications Administration of RANKL boosts thymic regeneration upon bone marrow transplantation Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator.Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition.Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells.Sex hormones have pervasive effects on thymic epithelial cells.Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells Aire controls gene expression in the thymic epithelium with ordered stochasticity Central tolerance to self revealed by the autoimmune regulator.Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells Proteome-wide survey of the autoimmune target repertoire in autoimmune polyendocrine syndrome type 1 Variation is function: Are single cell differences functionally important?: Testing the hypothesis that single cell variation is required for aggregate function Increased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus.Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla.Dual Identification and Analysis of Differentially Expressed Transcripts of Porcine PK-15 Cells and Toxoplasma gondii during in vitro Infection.Thymic exosomes promote the final maturation of thymocytes.Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK(+) medullary epithelial progenitors.Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells.MHC class I-associated peptides derive from selective regions of the human genome.Power analysis of single-cell RNA-sequencing experiments.Construction of a functional thymic microenvironment from pluripotent stem cells for the induction of central tolerance.AIRE: From promiscuous molecular partnerships to promiscuous gene expression.EBI2 contributes to the induction of thymic central tolerance in mice by promoting rapid motility of medullary thymocytes.Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity.Thymic stromal cell subsets for T cell development.AIRE expands: new roles in immune tolerance and beyond.Autoimmune regulator and self-tolerance - molecular and clinical aspects.JingleBells: A Repository of Immune-Related Single-Cell RNA-Sequencing Datasets.Generation of diversity in thymic epithelial cells.Childhood Polyarthritis As Early Manifestation of Autoimmune Polyendocrinopathy with Candidiasis and Ectodermal Dystrophy Syndrome.

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Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.

http://www.wikidata.org/entity/Q34590391

description

2014 nî lūn-bûn

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2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Population and single-cell gen ...... xpression in thymic epithelia.

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Population and single-cell gen ...... xpression in thymic epithelia.

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Population and single-cell gen ...... xpression in thymic epithelia.

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Population and single-cell gen ...... xpression in thymic epithelia.

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Population and single-cell gen ...... xpression in thymic epithelia.

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Population and single-cell gen ...... xpression in thymic epithelia.

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Genome Research

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Population and single-cell gen ...... xpression in thymic epithelia.

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Georg A Holländer

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Gretel Nusspaumer

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Mary E Deadman

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Noriko Shikama-Dorn

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Saule Zhanybekova

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Stephen N Sansom

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P2860

Differential expression analysis for sequence count data

Mapping and quantifying mammalian transcriptomes by RNA-Seq

Aire's partners in the molecular control of immunological tolerance

Structure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulator

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells.

Expression analysis of G Protein-Coupled Receptors in mouse macrophages

Deletional tolerance mediated by extrathymic Aire-expressing cells

Fast and accurate short read alignment with Burrows-Wheeler transform

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10.1101/GR.171645.113

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12

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24

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Iain C Macaulay

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2014-09-15T00:00:00Z

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265691124

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25224068

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4248310

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