Unusual resistance of ALR/Lt mouse beta cells to autoimmune destruction: role for beta cell-expressed resistance determinants - Test2 - elhamkhani - TriplyDB

Unusual resistance of ALR/Lt mouse beta cells to autoimmune destruction: role for beta cell-expressed resistance determinants

Unusual resistance of ALR/Lt mouse beta cells to autoimmune destruction: role for beta cell-expressed resistance determinants

http://www.wikidata.org/entity/Q34592193

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Nuclear and mitochondrial interaction involving mt-Nd2 leads to increased mitochondrial reactive oxygen species production mt-Nd2(a) Modifies resistance against autoimmune type 1 diabetes in NOD mice at the level of the pancreatic β-cell.Commonalities of genetic resistance to spontaneous autoimmune and free radical--mediated diabetes.Methods to assess beta cell death mediated by cytotoxic T lymphocytes Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes.Oxidative stress and redox modulation potential in type 1 diabetes.Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes.Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells.NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.Resistance of the target islet tissue to autoimmune destruction contributes to genetic susceptibility in Type 1 diabetes.Utility of murine models for the study of spontaneous autoimmune type 1 diabetes.Extracellular high-mobility group box 1 acts as an innate immune mediator to enhance autoimmune progression and diabetes onset in NOD mice Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes Role of increased ROS dissipation in prevention of T1D.The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis.Role of genetics in resistance to type 1 diabetes.Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic beta-cells.Is There a Role for Bioactive Lipids in the Pathobiology of Diabetes Mellitus?The Type 1 Diabetes-Resistance Locus Idd22 Controls Trafficking of Autoreactive CTLs into the Pancreatic Islets of NOD Mice.

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Unusual resistance of ALR/Lt mouse beta cells to autoimmune destruction: role for beta cell-expressed resistance determinants

http://www.wikidata.org/entity/Q34592193

description

2001 nî lūn-bûn

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2001 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2001 թվականի հունվարին հրատարակված գիտական հոդված

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2001年の論文

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Unusual resistance of ALR/Lt m ...... ressed resistance determinants

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Unusual resistance of ALR/Lt m ...... ressed resistance determinants

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Unusual resistance of ALR/Lt m ...... ressed resistance determinants

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Proceedings of the National Academy of Sciences of the United States of America

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Unusual resistance of ALR/Lt m ...... ressed resistance determinants

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A Savinov

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C E Mathews

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D V Serreze

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E H Leiter

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R T Graser

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P2860

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.

Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping

Pancreatic beta cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes

Nuclear c-Myc plays an important role in the cytotoxicity of tumor necrosis factor alpha in tumor cells

Heat shock protein hsp70 overexpression confers resistance against nitric oxide.

C-JUN/AP-1 as possible mediators of tumor necrosis factor-alpha-induced apoptotic response in mouse JB6 tumor cells.

CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.

Targeted overexpression of Cu/Zn superoxide dismutase protects pancreatic beta-cells against oxidative stress.

Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction.

An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus.

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235-240

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scholarly article

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10.1073/PNAS.98.1.235

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1

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98

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2001-01-01T00:00:00Z

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12193247

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11136257

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14574

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