Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists? - Test2 - elhamkhani - TriplyDB

Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists?

Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists?

http://www.wikidata.org/entity/Q34613452

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PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pups.Selective targeting of the α5-subunit of GABAA receptors relaxes airway smooth muscle and inhibits cellular calcium handling Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats?GABA(A) receptor α subunits differentially contribute to diazepam tolerance after chronic treatment.Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABAA receptors containing the α5 subunit.GABAA-positive modulator selective discriminative stimulus effects of 1,1,1-trichloroethane vapor Contribution of alpha1 subunit-containing gamma-aminobutyric acidA (GABAA) receptors to motor-impairing effects of benzodiazepines in squirrel monkeys Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABAA Receptor Positive Allosteric Modulator.Disinhibition, an emerging pharmacology of learning and memory Searching for perfect sleep: the continuing evolution of GABAA receptor modulators as hypnotics.Enhancing the function of alpha5-subunit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states.The inhibitory GABA system as a therapeutic target for cognitive symptoms in schizophrenia: investigational agents in the pipeline.GABA(A) receptor physiology and its relationship to the mechanism of action of the 1,5-benzodiazepine clobazam.Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABAA receptors.The differential role of alpha1- and alpha5-containing GABA(A) receptors in mediating diazepam effects on spontaneous locomotor activity and water-maze learning and memory in rats.Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties.GABA(A) Receptor Dynamics and Constructing GABAergic Synapses.The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats PWZ-029, an inverse agonist selective for α₅ GABAA receptors, improves object recognition, but not water-maze memory in normal and scopolamine-treated rats.GABAergic inhibitory neurons as therapeutic targets for cognitive impairment in schizophrenia.

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Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists?

http://www.wikidata.org/entity/Q34613452

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2007 nî lūn-bûn

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2007 թուականի Մարտին հրատարակուած գիտական յօդուած

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2007 թվականի մարտին հրատարակված գիտական հոդված

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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Neuropsychopharmacology

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Are GABAA receptors containing ...... benzodiazepine site agonists?

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Dragan I Obradović

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Dubravko R Bokonjić

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James M Cook

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Miroslav M Savić

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Nenad D Ugresić

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Roman Furtmüller

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Shengming Huang

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Terry Clayton

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P2860

The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagoclone

Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors

Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates

Limitations on the use of benzodiazepines in anxiety and insomnia: are they justified?

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

Subunit composition, distribution and function of GABA(A) receptor subtypes.

TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.

GABA-A receptors: a viable target for novel anxiolytics?

GABA-based therapeutic approaches: GABAA receptor subtype functions.

Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics.

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332-339

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10.1038/SJ.NPP.1301403

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2

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33

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Werner Sieghart

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