Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection. - Test2 - elhamkhani - TriplyDB

Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection.

Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection.

http://www.wikidata.org/entity/Q34641933

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Reversing Gut Damage in HIV Infection: Using Non-Human Primate Models to Instruct Clinical Research A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3 PolyICLC Exerts Pro- and Anti-HIV Effects on the DC-T Cell Milieu In Vitro and In Vivo Bottlenecks in HIV-1 transmission: insights from the study of founder viruses The V1V2 Region of HIV-1 gp120 Forms a Five-Stranded Beta Barrel.Effectiveness of UNAIDS targets and HIV vaccination across 127 countries.Characteristics of HIV target CD4 T cells collected using different sampling methods from the genital tract of HIV seronegative women Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge.Retinoic acid imprints a mucosal-like phenotype on dendritic cells with an increased ability to fuel HIV-1 infection.South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on α4β7 for replication.Macaque models of enhanced susceptibility to HIV.Phenotypic and Functional Characterization of Monoclonal Antibodies with Specificity for Rhesus Macaque CD200, CD200R and Mincle Identification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin Receptor.Human Blood-Circulating Basophils Capture HIV-1 and Mediate Viral trans-Infection of CD4+ T Cells.Comparable Antigenicity and Immunogenicity of Oligomeric Forms of a Novel, Acute HIV-1 Subtype C gp145 Envelope for Use in Preclinical and Clinical Vaccine Research Relationship of menstrual cycle and vaginal infection in female rhesus macaques challenged with repeated, low doses of SIVmac251.HIV transmission biology: translation for HIV prevention.Differentiating founder and chronic HIV envelope sequences.Species-specific differences in the expression and regulation of α4β7 integrin in various nonhuman primates Signatures in Simian Immunodeficiency Virus SIVsmE660 Envelope gp120 Are Associated with Mucosal Transmission but Not Vaccination Breakthrough in Rhesus Macaques Human Mucosal Mast Cells Capture HIV-1 and Mediate Viral trans-Infection of CD4+ T Cells.Differences in expression of gut-homing receptors on CD4+ T cells in black and white HIV-negative men who have sex with men Progesterone Levels Associate with a Novel Population of CCR5+CD38+ CD4 T Cells Resident in the Genital Mucosa with Lymphoid Trafficking Potential.Worldwide Genetic Features of HIV-1 Env α4β7 Binding Motif: The Local Dissemination Impact of the LDI Tripeptide.Initiation of antiretroviral therapy before detection of colonic infiltration by HIV reduces viral reservoirs, inflammation and immune activation.Pair housing of Macaques: A review of partner selection, introduction techniques, monitoring for compatibility, and methods for long-term maintenance of pairs.Antibodies to P-selectin glycoprotein ligand-1 block dendritic cell-mediated enterovirus 71 transmission and prevent virus-induced cells death.Ontogeny of CD4+ T Lymphocytes With Phenotypic Susceptibility to HIV-1 During Exclusive and Nonexclusive Breastfeeding in HIV-1-Exposed Ugandan Infants.Complex immune correlates of protection in HIV-1 vaccine efficacy trials.Virus-Host Gene Interactions Define HIV-1 Disease Progression.Extracellular Matrix Proteins Mediate HIV-1 gp120 Interactions with α4β7.Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing.Early initiation of antiretroviral treatment postSIV infection does not resolve lymphoid tissue activation.Acute Simian Immunodeficiency Virus Infection Triggers Early and Transient Interleukin-7 Production in the Gut, Leading to Enhanced Local Chemokine Expression and Intestinal Immune Cell Homing.Glycosylation and oligomeric state of envelope protein might influence HIV-1 virion capture by α4β7 integrin.Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy.Brief Report: A High Rate of β7+ Gut-Homing Lymphocytes in HIV-Infected Immunological Nonresponders is Associated With Poor CD4 T-Cell Recovery During Suppressive HAART The Role of Integrin Expressing Cells in Modulating Disease Susceptibility and Progression (January 2016).The HIV-1 transmission bottleneck.Hormonal Contraception and HIV-1 Acquisition: Biological Mechanisms.

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Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection.

http://www.wikidata.org/entity/Q34641933

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2014 nî lūn-bûn

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2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Nature Medicine

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Ann E Mayne

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Brianne Kallam

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Dawn Little

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Debra Hanson

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Ellen N Kersh

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Fatima Nawaz

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Francois Villinger

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James Arthos

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Janet M McNicholl

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Keith A Reimann

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P2860

Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract

HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

Preclinical assessment of HIV vaccines and microbicides by repeated low-dose virus challenges.

In captive rhesus macaques, cervicovaginal inflammation is common but not associated with the stable polymicrobial microbiome

TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus Monkeys

Monoclonal antibodies to the V2 domain of MN-rgp120: fine mapping of epitopes and inhibition of α4β7 binding

Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection

Assessing vaccine effects in repeated low-dose challenge experiments.

Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility.

Preliminary in vivo efficacy studies of a recombinant rhesus anti-alpha(4)beta(7) monoclonal antibody.

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1397-1400

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10.1038/NM.3715

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12

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20

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Nagadenahalli Byrareddy Siddappa

Aftab A. Ansari

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2014-11-24T00:00:00Z

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270568069

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1016825036

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25419708

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Simian immunodeficiency virus

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4257865

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