How might qinghaosu (artemisinin) and related compounds kill the intraerythrocytic malaria parasite? A chemist's view.
about
Identification of an antimalarial synthetic trioxolane drug development candidateArtemisinin-based combination therapies: a vital tool in efforts to eliminate malariaCysteamine, the molecule used to treat cystinosis, potentiates the antimalarial efficacy of artemisinin.Chiral phosphoric acid catalyzed peroxidation of iminesDiscovery, mechanisms of action and combination therapy of artemisininMechanisms of in situ activation for peroxidic antimalarials.Emerging issues in traditional Chinese medicine.The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents.Drug discovery and development for neglected parasitic diseases.Selection of a trioxaquine as an antimalarial drug candidate.Preparation of bicyclic 1,2,4-trioxanes from gamma,delta-unsaturated ketonesRecent highlights in antimalarial drug resistance and chemotherapy research.Palladium(II)-catalyzed cyclization of unsaturated hydroperoxides for the synthesis of 1,2-dioxanes.Malaria and iron: history and review.Intravenous artesunate versus intravenous quinine in the treatment of severe falciparum malaria: a retrospective evaluation from a UK centreTetraoxanes: synthetic and medicinal chemistry perspective.Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potentialBioinformatic and experimental fishing for artemisinin-interacting proteins from human nasopharyngeal cancer cells.Pharmacokinetic study and bioavailability of a novel synthetic trioxane antimalarial compound 97/63 in rats.Evidence that haem iron in the malaria parasite is not needed for the antimalarial effects of artemisinin.Endoperoxide synthesis by photocatalytic aerobic [2 + 2 + 2] cycloadditionsAlkylation of human hemoglobin A0 by the antimalarial drug artemisinin.Artemisinin and heme.Medicinal chemistry: a worthy adversary for malaria.Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins.Difunctionalization of alkenes with iodine and tert-butyl hydroperoxide (TBHP) at room temperature for the synthesis of 1-(tert-butylperoxy)-2-iodoethanes.Synthetic Approaches to Mono- and Bicyclic Perortho-Esters with a Central 1,2,4-Trioxane Ring as the Privileged Lead Structure in Antimalarial and Antitumor-Active Peroxides and Clarification of the Peroxide Relevance.
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P2860
How might qinghaosu (artemisinin) and related compounds kill the intraerythrocytic malaria parasite? A chemist's view.
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2002 nî lūn-bûn
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2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
How might qinghaosu (artemisin ...... ia parasite? A chemist's view.
@ast
How might qinghaosu (artemisin ...... ia parasite? A chemist's view.
@en
How might qinghaosu
@nl
type
label
How might qinghaosu (artemisin ...... ia parasite? A chemist's view.
@ast
How might qinghaosu (artemisin ...... ia parasite? A chemist's view.
@en
How might qinghaosu
@nl
prefLabel
How might qinghaosu (artemisin ...... ia parasite? A chemist's view.
@ast
How might qinghaosu (artemisin ...... ia parasite? A chemist's view.
@en
How might qinghaosu
@nl
P356
P1476
How might qinghaosu (artemisin ...... ia parasite? A chemist's view.
@en
P2093
P304
P356
10.1021/AR000080B
P407
P577
2002-05-01T00:00:00Z