Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons
about
Sodium channel molecular conformations and antiarrhythmic drug affinityMolecular analysis of the Na+ channel blocking actions of the novel class I anti-arrhythmic agent RSD 921The hitchhiker's guide to the voltage-gated sodium channel galaxyCommon molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channelsInteractions of monovalent cations with sodium channels in squid axon. I. Modification of physiological inactivation gatingMolecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na+ channel.State-dependent block underlies the tissue specificity of lidocaine action on batrachotoxin-activated cardiac sodium channels.Modification of cardiac Na+ channels by batrachotoxin: effects on gating, kinetics, and local anesthetic binding.Dissecting lidocaine action: diethylamide and phenol mimic separate modes of lidocaine block of sodium channels from heart and skeletal muscleQX-314 restores gating charge immobilization abolished by chloramine-T treatment in squid giant axons.Characterization of cocaine-induced block of cardiac sodium channels.Kinetic analysis of phasic inhibition of neuronal sodium currents by lidocaine and bupivacaineAminopyridines block an inactivating potassium current having slow recovery kinetics.Isoform-specific lidocaine block of sodium channels explained by differences in gatingMolecular mechanism of allosteric modification of voltage-dependent sodium channels by local anestheticsBlockage of squid axon potassium conductance by internal tetra-N-alkylammonium ions of various sizes.Block and inactivation of sodium channels in nerve by amino acid derivatives. II. Dependence on temperature and drug concentrationThe effect of tetramethylammonium on single sodium channel currents.n-Alkanols potentiate sodium channel inactivation in squid giant axonsCurrent-dependent block of nerve membrane sodium channels by paragracine.Interaction of nonylguanidine with the sodium channel.Solvent substitution as a probe of channel gating in Myxicola. Effects of D2O on kinetic properties of drugs that occlude channels.A quantitative description of QX222 blockade of sodium channels in squid axons.TEA prevents inactivation while blocking open K+ channels in human T lymphocytes.Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics.Kinetic analysis of sodium channel block by internal methylene blue in pronased crayfish giant axons.Na channel activation gate modulates slow recovery from use-dependent block by local anesthetics in squid giant axonsThe channel-blocking action of methonium compounds on rat submandibular ganglion cells. 1983Quinidine blocks cardiac sodium channels during opening and slow inactivation in guinea-pig papillary muscle.Blockade by local anaesthetics of the single Ca(2+)-activated K+ channel in rat hippocampal neuronesThe channel-blocking action of methonium compounds on rat submandibular ganglion cells.Sodium channel inactivation: molecular determinants and modulation.Some kinetic and steady-state properties of sodium channels after removal of inactivation.Local anesthetics QX 572 and benzocaine act at separate sites on the batrachotoxin-activated sodium channel.Current-dependent block of endplate channels by guanidine derivativesInteractions of monovalent cations with sodium channels in squid axon. II. Modification of pharmacological inactivation gatingInhibition of sodium currents by local anesthetics in chloramine-T-treated squid axons. The role of channel activation.Binding of benzocaine in batrachotoxin-modified Na+ channels. State-dependent interactions.Functional consequences of lidocaine binding to slow-inactivated sodium channelsMolecular action of lidocaine on the voltage sensors of sodium channels
P2860
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P2860
Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons
description
1978 nî lūn-bûn
@nan
1978 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1978 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1978年の論文
@ja
1978年論文
@yue
1978年論文
@zh-hant
1978年論文
@zh-hk
1978年論文
@zh-mo
1978年論文
@zh-tw
1978年论文
@wuu
name
Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons
@ast
Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons
@en
Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons
@nl
type
label
Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons
@ast
Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons
@en
Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons
@nl
prefLabel
Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons
@ast
Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons
@en
Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons
@nl
P2860
P1433
P1476
Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons
@en
P2093
Cahalan MD
P2860
P304
P356
10.1016/S0006-3495(78)85449-6
P407
P577
1978-08-01T00:00:00Z