A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation
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JNK Signaling: Regulation and Functions Based on Complex Protein-Protein PartnershipsSuper-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmentiMechanism Underlying I B Kinase Activation Mediated by the Linear Ubiquitin Chain Assembly ComplexMolecular basis for specificity of the Met1-linked polyubiquitin signalTyrosine phosphorylation allows integration of multiple signaling inputs by IKKβProbing the Solution Structure of IκB Kinase (IKK) Subunit γ and Its Interaction with Kaposi Sarcoma-associated Herpes Virus Flice-interacting Protein and IKK Subunit β by EPR SpectroscopyStructural Basis for the Activation of IKK1/αOscillation dynamics underlie functional switching of NF-κB for B-cell activation.IκB kinase β (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor κB (NFκB) signaling.The IκB kinase complex in NF-κB regulation and beyond.Quantitative analysis of the TNF-α-induced phosphoproteome reveals AEG-1/MTDH/LYRIC as an IKKβ substrate.Dihydromyricetin suppresses inflammatory responses in vitro and in vivo through inhibition of IKKβ activity in macrophages.Mutation of cysteine 46 in IKK-beta increases inflammatory responses.IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.Molecular control of the NEMO family of ubiquitin-binding proteins.Regulation of NF-κB by TNF family cytokines.Probing kinase activation and substrate specificity with an engineered monomeric IKK2Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation.Signaling via the NFκB system.Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-κB activation.Calcineurin β protects brain after injury by activating the unfolded protein response.An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation.Evidence for M1-Linked Polyubiquitin-Mediated Conformational Change in NEMO.Global Identification of Small Ubiquitin-related Modifier (SUMO) Substrates Reveals Crosstalk between SUMOylation and Phosphorylation Promotes Cell Migration.The fructose-2,6-bisphosphatase TIGAR suppresses NF-κB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC.Mechanism of vaccinia viral protein B14 mediated inhibition of IκB kinase β activation.Linear ubiquitin chains: NF-κB signalling, cell death and beyond.LASSBio-1829 Hydrochloride: Development of a New Orally Active N-Acylhydrazone IKK2 Inhibitor with Anti-inflammatory Properties.T cell receptor signals to NF-κB are transmitted by a cytosolic p62-Bcl10-Malt1-IKK signalosome.Molecular basis of Tousled-Like Kinase 2 activation.Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ InhibitorsOncogenic mutations in IKKβ function through global changes induced by K63-linked ubiquitination and result in autocrine stimulation
P2860
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P2860
A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
A structural basis for IκB kin ...... ent trans auto-phosphorylation
@ast
A structural basis for IκB kin ...... ent trans auto-phosphorylation
@en
A structural basis for IκB kin ...... ent trans auto-phosphorylation
@nl
type
label
A structural basis for IκB kin ...... ent trans auto-phosphorylation
@ast
A structural basis for IκB kin ...... ent trans auto-phosphorylation
@en
A structural basis for IκB kin ...... ent trans auto-phosphorylation
@nl
prefLabel
A structural basis for IκB kin ...... ent trans auto-phosphorylation
@ast
A structural basis for IκB kin ...... ent trans auto-phosphorylation
@en
A structural basis for IκB kin ...... ent trans auto-phosphorylation
@nl
P2093
P2860
P921
P1433
P1476
A structural basis for IκB kin ...... ent trans auto-phosphorylation
@en
P2093
Alexander Hoffmann
Amanda J Fusco
Arthur V Hauenstein
Bärbel Schröfelbauer
De-Bin Huang
Gourisankar Ghosh
Inder M Verma
Smarajit Polley
Xiangyang Zhong
P2860
P304
P356
10.1371/JOURNAL.PBIO.1001581
P407
P50
P577
2013-06-11T00:00:00Z