S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models. - Test2 - elhamkhani - TriplyDB

S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models.

S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models.

http://www.wikidata.org/entity/Q34784727

about

A Review of Biomarkers in Mood and Psychotic Disorders: A Dissection of Clinical vs. Preclinical Correlates Efficacy of the novel antidepressant agomelatine for anxiety symptoms in major depression Captodiamine, a putative antidepressant, enhances hypothalamic BDNF expression in vivo by synergistic 5-HT2c receptor antagonism and sigma-1 receptor agonism Dual- and triple-acting agents for treating core and co-morbid symptoms of major depression: novel concepts, new drugs Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC Adult neurogenesis and mental illness.Differential distribution of serotonin receptor subtypes in BNST(ALG) neurons: modulation by unpredictable shock stress The age of anxiety: role of animal models of anxiolytic action in drug discovery.The clinical implications of mouse models of enhanced anxiety.Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT2C receptor-dependent pathways Protective effects of phosphodiesterase 2 inhibitor on depression- and anxiety-like behaviors: involvement of antioxidant and anti-apoptotic mechanisms A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference.The serotonin 2C receptor antagonist SB 242084 exhibits abuse-related effects typical of stimulants in squirrel monkeys Antidepressant-like effects of a novel 5-HT3 receptor antagonist 6z in acute and chronic murine models of depression.The role of serotonin receptor subtypes in treating depression: a review of animal studies GABAergic control of depression-related brain states Serotonin2C Receptors and the Motor Control of Oral Activity The effects of the dopamine stabilizer (-)-OSU6162 on aggressive and sexual behavior in rodents 5-HT2CR blockade in the amygdala conveys analgesic efficacy to SSRIs in a rat model of arthritis pain.Mechanism of action of trazodone: a multifunctional drug.Mode of action of agomelatine: synergy between melatonergic and 5-HT2C receptors.5-HT2 ligands in the treatment of anxiety and depression.Serotonin: from top to bottom.Multiple controls exerted by 5-HT2C receptors upon basal ganglia function: from physiology to pathophysiology.Agomelatine: mechanism of action and pharmacological profile in relation to antidepressant properties.New insights on the antidepressant discontinuation syndrome.Altering the course of schizophrenia: progress and perspectives.BDNF isoforms: a round trip ticket between neurogenesis and serotonin?Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models.Electrophysiological effects of repeated administration of agomelatine on the dopamine, norepinephrine, and serotonin systems in the rat brain.Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity.Marine cyanobacteria-derived serotonin receptor 2C active fraction induces psychoactive behavioral effects in mice Synergistic mechanisms in the modulation of the neurotrophin BDNF in the rat prefrontal cortex following acute agomelatine administration.Serotonin 2C receptor antagonists induce fast-onset antidepressant effects.Like melatonin, agomelatine (S20098) increases the amplitude of oscillations of two clock outputs: melatonin and temperature rhythms.Pinching spine: A potential treatment for depression.Asenapine reduces anxiety-related behaviours in rat conditioned fear stress model.The frontal cortex as a network hub controlling mood and cognition: Probing its neurochemical substrates for improved therapy of psychiatric and neurological disorders.Evidence for a role of 5-HT2C receptors in the motor aspects of performance, but not the efficacy of food reinforcers, in a progressive ratio schedule.Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice.

P2860

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P2860

S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models.

http://www.wikidata.org/entity/Q34784727

description

2008 nî lūn-bûn

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2008 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2008 թվականի հունիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

S32006, a novel 5-HT2C recepto ...... c properties in rodent models.

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Amélie Soumier

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Anne Dekeyne

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Annie Daszuta

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Clotilde Mannoury la Cour

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Florence Serres

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Françoise Lejeune

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Gunnar Flik

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Jean-Michel Rivet

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P2860

Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety

In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties

Dopamine and serotonin: influences on male sexual behavior.

m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT(2C) receptors but not 5-HT(2A) or 5-HT(2B) receptors.

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