Widespread purifying selection at polymorphic sites in human protein-coding loci. - Test2 - elhamkhani - TriplyDB

Widespread purifying selection at polymorphic sites in human protein-coding loci.

Widespread purifying selection at polymorphic sites in human protein-coding loci.

http://www.wikidata.org/entity/Q34791432

about

Selectionism and neutralism in molecular evolution Weak selection and protein evolution The evolutionary biology of poxviruses Tandem repeat copy-number variation in protein-coding regions of human genes.SNP500Cancer: a public resource for sequence validation, assay development, and frequency analysis for genetic variation in candidate genes Rapid fixation of a distinctive sequence motif in the 3′ noncoding region of the clade of West Nile virus invading North America Distinctive pattern of sequence polymorphism in the NS3 protein of hepatitis C virus type 1b reflects conflicting evolutionary pressures More effective purifying selection on RNA viruses than in DNA viruses Characterization of population-based variation and putative functional elements for the multiple-cancer susceptibility loci at 5p15.33 Evolutionary Migration of the Disjunct Salt Cress Eutrema salsugineum (= Thellungiella salsuginea, Brassicaceae) between Asia and North America Evolution of the bovine TLR gene family and member associations with Mycobacterium avium subspecies paratuberculosis infection Effects of natural selection on interpopulation divergence at polymorphic sites in human protein-coding Loci Reassortment of ancient neuraminidase and recent hemagglutinin in pandemic (H1N1) 2009 virus.SNPGenie: estimating evolutionary parameters to detect natural selection using pooled next-generation sequencing data A novel statistical method to estimate the effective SNP size in vertebrate genomes and categorized genomic regions.The evolution of gene expression QTL in Saccharomyces cerevisiae.Marked variation in predicted and observed variability of tandem repeat loci across the human genome.Relative effects of mutability and selection on single nucleotide polymorphisms in transcribed regions of the human genome Distribution and effects of nonsense polymorphisms in human genes.Domain duplication, divergence, and loss events in vertebrate Msx paralogs reveal phylogenomically informed disease markers.Diversity and evolution of 11 innate immune genes in Bos taurus taurus and Bos taurus indicus cattle The impact of single nucleotide polymorphism in monomeric alpha-amylase inhibitor genes from wild emmer wheat, primarily from Israel and Golan.Selection on amino acid substitutions in Arabidopsis.Purifying selection in deeply conserved human enhancers is more consistent than in coding sequences.A simple method for analyzing exome sequencing data shows distinct levels of nonsynonymous variation for human immune and nervous system genes.Mapping the landscape of host-pathogen coevolution: HLA class I binding and its relationship with evolutionary conservation in human and viral proteins.Evidence for abundant slightly deleterious polymorphisms in bacterial populations Looking for Darwin in all the wrong places: the misguided quest for positive selection at the nucleotide sequence level.Adaptation and constraint at Toll-like receptors in primates Assessment of the olfactory function in Italian patients with type 3 von Willebrand disease caused by a homozygous 253 Kb deletion involving VWF and TMEM16B/ANO2 Within-host nucleotide diversity of virus populations: insights from next-generation sequencing.Human pharmacogenomic variations and their implications for antifungal efficacy.PolyAna: analyzing synonymous and nonsynonymous polymorphic sites.Near-neutrality, robustness, and epigenetics.Adaptive evolution in humans revealed by the negative correlation between the polymorphism and fixation phases of evolution.Allelic Spectra of Risk SNPs Are Different for Environment/Lifestyle Dependent versus Independent Diseases.An association between polymorphism of the heme oxygenase-1 and -2 genes and age-related macular degeneration.Most rare missense alleles are deleterious in humans: implications for complex disease and association studies.Evolution of adaptive phenotypic traits without positive Darwinian selection.The abundance of deleterious polymorphisms in humans.

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P2860

Widespread purifying selection at polymorphic sites in human protein-coding loci.

http://www.wikidata.org/entity/Q34791432

description

2003 nî lūn-bûn

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2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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name

Widespread purifying selection at polymorphic sites in human protein-coding loci.

@ast

Widespread purifying selection at polymorphic sites in human protein-coding loci.

@en

Widespread purifying selection at polymorphic sites in human protein-coding loci.

@nl

type

label

Widespread purifying selection at polymorphic sites in human protein-coding loci.

@ast

Widespread purifying selection at polymorphic sites in human protein-coding loci.

@en

Widespread purifying selection at polymorphic sites in human protein-coding loci.

@nl

prefLabel

Widespread purifying selection at polymorphic sites in human protein-coding loci.

@ast

Widespread purifying selection at polymorphic sites in human protein-coding loci.

@en

Widespread purifying selection at polymorphic sites in human protein-coding loci.

@nl

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Proceedings of the National Academy of Sciences of the United States of America

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Widespread purifying selection at polymorphic sites in human protein-coding loci.

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Austin L Hughes

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Robert Welch

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Single nucleotide polymorphisms as tools in human genetics

Genetic traces of ancient demography

Slightly Deleterious Mutant Substitutions in Evolution

Initial sequencing and comparative analysis of the mouse genome

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

Searching for genetic determinants in the new millennium

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Features of evolution and expansion of modern humans, inferred from genomewide microsatellite markers

Near-neutrality in evolution of genes and gene regulation

Genetic variation among world populations: inferences from 100 Alu insertion polymorphisms

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