Widespread purifying selection at polymorphic sites in human protein-coding loci.
about
Selectionism and neutralism in molecular evolutionWeak selection and protein evolutionThe evolutionary biology of poxvirusesTandem repeat copy-number variation in protein-coding regions of human genes.SNP500Cancer: a public resource for sequence validation, assay development, and frequency analysis for genetic variation in candidate genesRapid fixation of a distinctive sequence motif in the 3′ noncoding region of the clade of West Nile virus invading North AmericaDistinctive pattern of sequence polymorphism in the NS3 protein of hepatitis C virus type 1b reflects conflicting evolutionary pressuresMore effective purifying selection on RNA viruses than in DNA virusesCharacterization of population-based variation and putative functional elements for the multiple-cancer susceptibility loci at 5p15.33Evolutionary Migration of the Disjunct Salt Cress Eutrema salsugineum (= Thellungiella salsuginea, Brassicaceae) between Asia and North AmericaEvolution of the bovine TLR gene family and member associations with Mycobacterium avium subspecies paratuberculosis infectionEffects of natural selection on interpopulation divergence at polymorphic sites in human protein-coding LociReassortment of ancient neuraminidase and recent hemagglutinin in pandemic (H1N1) 2009 virus.SNPGenie: estimating evolutionary parameters to detect natural selection using pooled next-generation sequencing dataA novel statistical method to estimate the effective SNP size in vertebrate genomes and categorized genomic regions.The evolution of gene expression QTL in Saccharomyces cerevisiae.Marked variation in predicted and observed variability of tandem repeat loci across the human genome.Relative effects of mutability and selection on single nucleotide polymorphisms in transcribed regions of the human genomeDistribution and effects of nonsense polymorphisms in human genes.Domain duplication, divergence, and loss events in vertebrate Msx paralogs reveal phylogenomically informed disease markers.Diversity and evolution of 11 innate immune genes in Bos taurus taurus and Bos taurus indicus cattleThe impact of single nucleotide polymorphism in monomeric alpha-amylase inhibitor genes from wild emmer wheat, primarily from Israel and Golan.Selection on amino acid substitutions in Arabidopsis.Purifying selection in deeply conserved human enhancers is more consistent than in coding sequences.A simple method for analyzing exome sequencing data shows distinct levels of nonsynonymous variation for human immune and nervous system genes.Mapping the landscape of host-pathogen coevolution: HLA class I binding and its relationship with evolutionary conservation in human and viral proteins.Evidence for abundant slightly deleterious polymorphisms in bacterial populationsLooking for Darwin in all the wrong places: the misguided quest for positive selection at the nucleotide sequence level.Adaptation and constraint at Toll-like receptors in primatesAssessment of the olfactory function in Italian patients with type 3 von Willebrand disease caused by a homozygous 253 Kb deletion involving VWF and TMEM16B/ANO2Within-host nucleotide diversity of virus populations: insights from next-generation sequencing.Human pharmacogenomic variations and their implications for antifungal efficacy.PolyAna: analyzing synonymous and nonsynonymous polymorphic sites.Near-neutrality, robustness, and epigenetics.Adaptive evolution in humans revealed by the negative correlation between the polymorphism and fixation phases of evolution.Allelic Spectra of Risk SNPs Are Different for Environment/Lifestyle Dependent versus Independent Diseases.An association between polymorphism of the heme oxygenase-1 and -2 genes and age-related macular degeneration.Most rare missense alleles are deleterious in humans: implications for complex disease and association studies.Evolution of adaptive phenotypic traits without positive Darwinian selection.The abundance of deleterious polymorphisms in humans.
P2860
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P2860
Widespread purifying selection at polymorphic sites in human protein-coding loci.
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
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2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
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2003年學術文章
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name
Widespread purifying selection at polymorphic sites in human protein-coding loci.
@ast
Widespread purifying selection at polymorphic sites in human protein-coding loci.
@en
Widespread purifying selection at polymorphic sites in human protein-coding loci.
@nl
type
label
Widespread purifying selection at polymorphic sites in human protein-coding loci.
@ast
Widespread purifying selection at polymorphic sites in human protein-coding loci.
@en
Widespread purifying selection at polymorphic sites in human protein-coding loci.
@nl
prefLabel
Widespread purifying selection at polymorphic sites in human protein-coding loci.
@ast
Widespread purifying selection at polymorphic sites in human protein-coding loci.
@en
Widespread purifying selection at polymorphic sites in human protein-coding loci.
@nl
P2093
P2860
P50
P356
P1476
Widespread purifying selection at polymorphic sites in human protein-coding loci.
@en
P2093
Austin L Hughes
Bernice Packer
Robert Welch
P2860
P304
15754-15757
P356
10.1073/PNAS.2536718100
P407
P577
2003-12-05T00:00:00Z