Folliculin contributes to VHL tumor suppressing activity in renal cancer through regulation of autophagy. - Test2 - elhamkhani - TriplyDB

Folliculin contributes to VHL tumor suppressing activity in renal cancer through regulation of autophagy.

Folliculin contributes to VHL tumor suppressing activity in renal cancer through regulation of autophagy.

http://www.wikidata.org/entity/Q34905447

about

Amino acid management in cancer Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells.Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn.Identification of Novel Epigenetic Markers of Prostate Cancer by NotI-Microarray Analysis The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.Folliculin directs the formation of a Rab34-RILP complex to control the nutrient-dependent dynamic distribution of lysosomes.Suppression of autophagy enhances preferential toxicity of paclitaxel to folliculin-deficient renal cancer cells Folliculin - A tumor suppressor at the intersection of metabolic signaling and membrane traffic.FLCN: The causative gene for Birt-Hogg-Dubé syndrome.Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation.

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P2860

Folliculin contributes to VHL tumor suppressing activity in renal cancer through regulation of autophagy.

http://www.wikidata.org/entity/Q34905447

description

2013 nî lūn-bûn

@nan

2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հուլիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Folliculin contributes to VHL ...... rough regulation of autophagy.

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Folliculin contributes to VHL ...... rough regulation of autophagy.

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Folliculin contributes to VHL ...... rough regulation of autophagy.

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type

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Folliculin contributes to VHL ...... rough regulation of autophagy.

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Folliculin contributes to VHL ...... rough regulation of autophagy.

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Folliculin contributes to VHL ...... rough regulation of autophagy.

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Folliculin contributes to VHL ...... rough regulation of autophagy.

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Folliculin contributes to VHL ...... rough regulation of autophagy.

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Folliculin contributes to VHL ...... rough regulation of autophagy.

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Folliculin contributes to VHL ...... rough regulation of autophagy.

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Emily Kellner

http://www.w3.org/2001/XMLSchema#string

Jacek Biesiada

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Jarek Meller

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Maria F Czyzyk-Krzeska

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Mario Medvedovic

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Maureen A Sartor

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Olga Mikhaylova

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Prabhat Bastola

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Ying Yi

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Yiwen Stratton

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P2860

Discovery of Novel DENN Proteins: Implications for the Evolution of Eukaryotic Intracellular Membrane Structures and Human Disease

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2

Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys

Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin

The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis

Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome

The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress.

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