Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current - Test2 - elhamkhani - TriplyDB

Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current

Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current

http://www.wikidata.org/entity/Q34957274

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Cancer stem cells and the tumor microenvironment: interplay in tumor heterogeneity PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic Drugs Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression.Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo.Chloride intracellular channel 1 regulates the antineoplastic effects of metformin in gallbladder cancer cells.Modulation of the inwardly rectifying potassium channel Kir4.1 by the pro-invasive miR-5096 in glioblastoma cells In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors The broad-spectrum anti-DNA virus agent cidofovir inhibits lung metastasis of virus-independent, FGF2-driven tumors.Endoplasmic reticulum targeting in Ewing's sarcoma by the alkylphospholipid analog edelfosine CLIC1 Inhibition Attenuates Vascular Inflammation, Oxidative Stress, and Endothelial Injury.The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma.Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1 Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo.Temozolomide in combination with metformin act synergistically to inhibit proliferation and expansion of glioma stem-like cells.Suppression of 14-3-3γ-mediated surface expression of ANO1 inhibits cancer progression of glioblastoma cells.Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2.Metformin reduces gastric cancer risk in patients with type 2 diabetes mellitus.Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells.Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies.Metformin enhances the radiosensitivity of human liver cancer cells to γ-rays and carbon ion beams.Metabolic Modification in Gastrointestinal Cancer Stem Cells: Characteristics and Therapeutic Approaches.Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells.The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma.A Metabolic Inhibitory Cocktail for Grave Cancers: Metformin, Pioglitazone and Lithium Combination in Treatment of Pancreatic Cancer and Glioblastoma Multiforme.Advances in β cell replacement and regeneration strategies for treating diabetes Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation.The inhibition of FGF receptor 1 activity mediates sorafenib antiproliferative effects in human malignant pleural mesothelioma tumor-initiating cells Metformin inhibits cell cycle progression of B-cell chronic lymphocytic leukemia cells.Therapeutic potential of the metabolic modulator phenformin in targeting the stem cell compartment in melanoma.Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors.Identification of Potent Chloride Intracellular Channel Protein 1 Inhibitors from Traditional Chinese Medicine through Structure-Based Virtual Screening and Molecular Dynamics Analysis.Phenotypical and Pharmacological Characterization of Stem-Like Cells in Human Pituitary Adenomas.Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.Development of an Injectable Slow-Release Metformin Formulation and Evaluation of Its Potential Antitumor Effects.The vesicular transfer of CLIC1 from glioblastoma to microvascular endothelial cells requires TRPM7 Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability Drug Repurposing of Metabolic Agents in Malignant Glioma Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma

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Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current

http://www.wikidata.org/entity/Q34957274

description

2014 nî lūn-bûn

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2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2014 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年论文

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Alessandra Pattarozzi

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Elisa Carra

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Erika Pizzi

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Federica Barbieri

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Marina Angelini

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Rodolfo Sirito

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P2860

Molecular cloning and expression of a chloride ion channel of cell nuclei

The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle

AMP-activated protein kinase: a target for drugs both ancient and modern

The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition

Unusual architecture of the p7 channel from hepatitis C virus

Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells

CLIC4 (p64H1) and its putative transmembrane domain form poorly selective, redox-regulated ion channels

Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or -independent manners

Metformin, a diabetes drug, eliminates tumor-initiating hepatocellular carcinoma cells

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10.18632/ONCOTARGET.2617

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