Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons.
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Intrinsic Hippocampal Excitability Changes of Opposite Signs and Different Origins in CA1 and CA3 Pyramidal Neurons Underlie Aging-Related Cognitive DeficitsFK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?Channelopathy pathogenesis in autism spectrum disordersIntegrative Transcriptome Profiling of Cognitive Aging and Its Preservation through Ser/Thr Protein Phosphatase RegulationDirect association of the reticulon protein RTN1A with the ryanodine receptor 2 in neuronsInhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged ratsAn X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity.Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease.Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease.Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus.Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2.Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.β amyloid peptide plaques fail to alter evoked neuronal calcium signals in APP/PS1 Alzheimer's disease micemTOR pathway and Ca²⁺ stores mobilization in aged smooth muscle cellsHippocampal calcium dysregulation at the nexus of diabetes and brain aging.Role of regucalcin in brain calcium signaling: involvement in aging.The changing landscape of voltage-gated calcium channels in neurovascular disorders and in neurodegenerative diseasesRyanodine receptors: physiological function and deregulation in Alzheimer disease.The ryanodine receptor provides high throughput Ca2+-release but is precisely regulated by networks of associated proteins: a focus on proteins relevant to phosphorylation.mTOR in Brain Physiology and Pathologies.Calcium, Reactive Oxygen Species, and Synaptic Plasticity.Neuronal Ryanodine Receptors in Development and Aging.Propagation of Intracellular Ca2+ Signals in Aged Exocrine Cells.FK506-Binding Protein 12.6/1b, a negative regulator of [Ca2+], rescues memory and restores genomic regulation in the hippocampus of aging rats.Novel calcium-related targets of insulin in hippocampal neurons.
P2860
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P2860
Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons.
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
name
Disrupting function of FK506-b ...... notype in hippocampal neurons.
@ast
Disrupting function of FK506-b ...... notype in hippocampal neurons.
@en
Disrupting function of FK506-b ...... notype in hippocampal neurons.
@nl
type
label
Disrupting function of FK506-b ...... notype in hippocampal neurons.
@ast
Disrupting function of FK506-b ...... notype in hippocampal neurons.
@en
Disrupting function of FK506-b ...... notype in hippocampal neurons.
@nl
prefLabel
Disrupting function of FK506-b ...... notype in hippocampal neurons.
@ast
Disrupting function of FK506-b ...... notype in hippocampal neurons.
@en
Disrupting function of FK506-b ...... notype in hippocampal neurons.
@nl
P2093
P2860
P1476
Disrupting function of FK506-b ...... notype in hippocampal neurons.
@en
P2093
Christopher M Norris
Eric M Blalock
Inga Kadish
John C Gant
Kuey-Chu Chen
Nada M Porter
Olivier Thibault
Philip W Landfield
P2860
P304
P356
10.1523/JNEUROSCI.4805-10.2011
P407
P577
2011-02-01T00:00:00Z