Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. - Test2 - elhamkhani - TriplyDB

Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK.

Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK.

http://www.wikidata.org/entity/Q34981610

about

Binge drinking: Burden of liver disease and beyond A Mechanistic Review of Mitophagy and Its Role in Protection against Alcoholic Liver Disease Insulin resistance in clinical and experimental alcoholic liver disease Effect of chronic alcohol consumption on the development and progression of non-alcoholic fatty liver disease (NAFLD)Alcoholic liver disease: the gut microbiome and liver cross talk New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases Alcoholic liver disease: pathogenesis and new therapeutic targets.New Insights into the Pathogenesis of Alcohol-Induced ER Stress and Liver Diseases Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse New therapeutic targets in alcoholic hepatitis.Animal Models of Alcoholic Liver Disease: Pathogenesis and Clinical Relevance Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol.Rectification of impaired adipose tissue methylation status and lipolytic response contributes to hepatoprotective effect of betaine in a mouse model of alcoholic liver disease.Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice.Altered gut microbial energy and metabolism in children with non-alcoholic fatty liver disease NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation Sirtuin 1 signaling and alcoholic fatty liver disease.Effect of multiple binge alcohol on diet-induced liver injury in a mouse model of obesity.Herbal SGR Formula Prevents Acute Ethanol-Induced Liver Steatosis via Inhibition of Lipogenesis and Enhancement Fatty Acid Oxidation in Mice Microbiota Protects Mice Against Acute Alcohol-Induced Liver Injury.Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice.Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice.Toll-like receptors in liver fibrosis: cellular crosstalk and mechanisms Short- or long-term high-fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: an important role for CXCL1.Cholesterol Enhances the Toxic Effect of Ethanol and Acetaldehyde in Primary Mouse Hepatocytes.Ethanol administration exacerbates the abnormalities in hepatic lipid oxidation in genetically obese mice.Adipose tissue-liver axis in alcoholic liver disease.Inflammation in alcoholic liver disease.Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emerging Role of Lipin-1.Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis.Liver Injury and the Activation of the Hepatic Myofibroblasts.Mouse model of chronic and binge ethanol feeding (the NIAAA model)The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts.Moderate alcohol consumption diminishes the development of non-alcoholic fatty liver disease (NAFLD) in ob/ob mice.Notch signaling and M1 macrophage activation in obesity-alcohol synergism Host homeostatic responses to alcohol-induced cellular stress in animal models of alcoholic liver disease.Pharmacotherapy of alcoholic liver disease in clinical practice.Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity.Pathogenesis of alcoholic liver disease.Alcohol and fat promote steatohepatitis: a critical role for fat-specific protein 27/CIDEC.

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P2860

Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK.

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2011年の論文

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J.JHEP.2010.12.034

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Journal of Hepatology

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Synergistic steatohepatitis by ...... reased adiponectin and p-AMPK.

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Alla Verlinsky

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Aurelia Lugea

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Cheng Ji

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Hidekazu Tsukamoto

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Jun Xu

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Keane K Y Lai

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Marcus P Cooper

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Samuel W French

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P2860

Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress

Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators

Prevalence of overweight and obesity in the United States, 1999-2004

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

ER stress triggers apoptosis by activating BH3-only protein Bim

Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity

Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice.

Intracellular ATP, a switch in the decision between apoptosis and necrosis.

Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype.

"Second hit" models of alcoholic liver disease.

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673-682

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scholarly article

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10.1016/J.JHEP.2010.12.034

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3

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55

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2011-01-21T00:00:00Z

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49776220

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21256905

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Steatohepatitis

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3094601

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