Decreased Npc1 gene dosage in mice is associated with weight gain.
about
Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C miceThe C57BL/6J Niemann-Pick C1 mouse model with decreased gene dosage has impaired glucose tolerance independent of body weight.Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice.Npc1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance.Mammalian NPC1 genes may undergo positive selection and human polymorphisms associate with type 2 diabetes.NPC1 in human white adipose tissue and obesity.Gene-diet interactions in childhood obesity.Genetic variation in the mouse model of Niemann Pick C1 affects female, as well as male, adiposity, and hepatic bile transporters but has indeterminate effects on caveolaeDifferential Association of Niemann-Pick C1 Gene Polymorphisms with Maternal Prepregnancy Overweight and Gestational Diabetes.The C57BL/6J Niemann-Pick C1 mouse model with decreased gene dosage is susceptible to increased weight gain when fed a high-fat diet: Confirmation of a gene-diet interactionThe Niemann-Pick C1 gene is downregulated in livers of C57BL/6J mice by dietary fatty acids, but not dietary cholesterol, through feedback inhibition of the SREBP pathway.The genetics of childhood obesity and interaction with dietary macronutrientsEvaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples.Neurological Dysfunction in Early Maturity of a Model for Niemann-Pick C1 Carrier Status.The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain through differential regulation of central energy metabolism pathways.Gene-nutrient interactions and susceptibility to human obesity.Predicting causal variants affecting expression by using whole-genome sequencing and RNA-seq from multiple human tissues.The extending spectrum of NPC1-related human disorders: from Niemann-Pick C1 Disease to obesity.
P2860
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P2860
Decreased Npc1 gene dosage in mice is associated with weight gain.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Decreased Npc1 gene dosage in mice is associated with weight gain.
@ast
Decreased Npc1 gene dosage in mice is associated with weight gain.
@en
type
label
Decreased Npc1 gene dosage in mice is associated with weight gain.
@ast
Decreased Npc1 gene dosage in mice is associated with weight gain.
@en
prefLabel
Decreased Npc1 gene dosage in mice is associated with weight gain.
@ast
Decreased Npc1 gene dosage in mice is associated with weight gain.
@en
P2093
P2860
P356
P1433
P1476
Decreased Npc1 gene dosage in mice is associated with weight gain.
@en
P2093
David Jelinek
Randall A Heidenreich
Robert P Erickson
William S Garver
P2860
P304
P356
10.1038/OBY.2009.415
P577
2009-11-12T00:00:00Z