Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion.
about
The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for TreatmentInnate immunity at mucosal surfaces: the IRE1-RIDD-RIG-I pathwayEmerging functions of the unfolded protein response in immunityEndoplasmic reticulum stress and type 2 diabetesInvolvement of the IRE1α-XBP1 pathway and XBP1s-dependent transcriptional reprogramming in metabolic diseasesPancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of HyperglycemiaMolecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor MicroenvironmentPhysiological IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunityToll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritisThe unfolded protein response in immunity and inflammationMechanisms for insulin resistance: common threads and missing linksAging and sleep deprivation induce the unfolded protein response in the pancreas: implications for metabolism.Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease.Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes.Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.Lack of XBP-1 impedes murine cytomegalovirus gene expression.Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response.Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass.IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis.Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress.Epithelial Xbp1 is required for cellular proliferation and differentiation during mammary gland developmentIRE1α activation protects mice against acetaminophen-induced hepatotoxicityPancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes.The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells.Type 2 diabetes as a protein misfolding disease.IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein SynthesisAntioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis.The impact of the unfolded protein response on human diseaseInsulin demand regulates β cell number via the unfolded protein response.The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis.Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response.Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation.PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1.Circadian control of β-cell function and stress responses.Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell FunctionFailure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetesProinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes.X-box binding protein 1 is essential for insulin regulation of pancreatic α-cell function.Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences.
P2860
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P2860
Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Dual and opposing roles of the ...... cessing and insulin secretion.
@ast
Dual and opposing roles of the ...... cessing and insulin secretion.
@en
type
label
Dual and opposing roles of the ...... cessing and insulin secretion.
@ast
Dual and opposing roles of the ...... cessing and insulin secretion.
@en
prefLabel
Dual and opposing roles of the ...... cessing and insulin secretion.
@ast
Dual and opposing roles of the ...... cessing and insulin secretion.
@en
P2093
P2860
P356
P1476
Dual and opposing roles of the ...... cessing and insulin secretion.
@en
P2093
Ann-Hwee Lee
Gökhan S Hotamisligil
Keely Heidtman
Laurie H Glimcher
P2860
P304
P356
10.1073/PNAS.1105564108
P407
P577
2011-05-09T00:00:00Z