Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches - Test2 - elhamkhani - TriplyDB

Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches

Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches

http://www.wikidata.org/entity/Q35034398

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DNA triplet repeat expansion and mismatch repair Ups and Downs: Mechanisms of Repeat Instability in the Fragile X-Related Disorders MutLα heterodimers modify the molecular phenotype of Friedreich ataxia.A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington's disease mice RNA-protein interactions in unstable microsatellite diseases.Modifiers of (CAG)(n) instability in Machado-Joseph disease (MJD/SCA3) transmissions: an association study with DNA replication, repair and recombination genes.Heterozygosity for a hypomorphic Polβ mutation reduces the expansion frequency in a mouse model of the Fragile X-related disorders.Repeat instability during DNA repair: Insights from model systems MSH3 Promotes Dynamic Behavior of Trinucleotide Repeat Tracts In Vivo.The Repeat Expansion Diseases: The dark side of DNA repair.Identification of Genetic Factors that Modify Clinical Onset of Huntington's Disease.Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington's Disease R6/1 Mice.Roles for mismatch repair family proteins in promoting meiotic crossing over.Recent advances in genetics of chorea Crosstalk between MSH2-MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair.CGG-repeat dynamics and FMR1 gene silencing in fragile X syndrome stem cells and stem cell-derived neurons.Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington's Disease Knock-In Mice.Chromatin regulation of DNA damage repair and genome integrity in the central nervous system.Genetic modifiers of Huntington's disease.The dual nature of mismatch repair as antimutator and mutator: for better or for worse.The Complexity of Clinical Huntington's Disease: Developments in Molecular Genetics, Neuropathology and Neuroimaging Biomarkers.Ethidium Bromide Modifies The Agarose Electrophoretic Mobility of CAG•CTG Alternative DNA Structures Generated by PCR.Huntington Disease: Linking Pathogenesis to the Development of Experimental Therapeutics.Close encounters: Moving along bumps, breaks, and bubbles on expanded trinucleotide tracts.An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes.Genetic Background Limits Generalizability of Genotype-Phenotype Relationships.Cytosine deamination and base excision repair cause R-loop-induced CAG repeat fragility and instability in Saccharomyces cerevisiae.MutSβ abundance and Msh3 ATP hydrolysis activity are important drivers of CTG•CAG repeat expansions.High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.An infant with MLH3 variants, FOXG1-duplication and multiple, benign cranial and spinal tumors: A clinical exome sequencing study.R-loops: targets for nuclease cleavage and repeat instability.Coexistence of MLH3 germline variants in colon cancer patients belonging to families with Lynch syndrome-associated brain tumors.A modifier of Huntington's disease onset at the MLH1 locus.The central role of DNA damage and repair in CAG repeat diseases.The p. R151C Polymorphism in MC1R Gene Modifies the Age of Onset in Spanish Huntington's Disease Patients.GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one.HttQ111/+ Huntington's Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction.Huntington disease Regulatory mechanisms of incomplete huntingtin mRNA splicing

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Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches

http://www.wikidata.org/entity/Q35034398

description

2013 nî lūn-bûn

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2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年论文

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Mismatch repair genes Mlh1 and ...... -wide and candidate approaches

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Mismatch repair genes Mlh1 and ...... -wide and candidate approaches

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Mismatch repair genes Mlh1 and ...... -wide and candidate approaches

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Mismatch repair genes Mlh1 and ...... -wide and candidate approaches

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Mismatch repair genes Mlh1 and ...... -wide and candidate approaches

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Mismatch repair genes Mlh1 and ...... -wide and candidate approaches

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JOURNAL.PGEN.1003930

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Mismatch repair genes Mlh1 and ...... -wide and candidate approaches

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Alejandro Lloret

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Andrew Kirby

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Caixia Hou

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Christopher E Pearson

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Edith Lopez

http://www.w3.org/2001/XMLSchema#string

Ella Dragileva

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Gagan B Panigrahi

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Jason St Claire

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Jolene R Guide

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Kim Holloway

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The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

A universal mechanism ties genotype to phenotype in trinucleotide diseases

A new mathematical model for relative quantification in real-time RT-PCR

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

A method and server for predicting damaging missense mutations

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination.

The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations.

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e1003930

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scholarly article

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10.1371/JOURNAL.PGEN.1003930

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10

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9

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Mark Joseph Daly

Ricardo Mouro Pinto

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2013-10-31T00:00:00Z

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258350622

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24204323

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Huntington disease

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3814320

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